THE PRODUCTION OF PERSISTENT ARTERIAL HYPERTENSION BY CELLOPHANE PERINEPHRITIS
THE PRODUCTION OF PERSISTENT ARTERIAL HYPERTENSION BY CELLOPHANE PERINEPHRITIS
复制标题
玻璃纸肾周炎造成持续性动脉高血压
DOI：
--
复制
发表时间：
1939
期刊：
影响因子：
--
通讯作者：
I. Page
中科院分区：
文献类型：
--
作者：
I. Page
肾周炎显然还没有被认为是动脉高血压的可能原因。偶尔，由于某种原因肾实质受到慢性压迫的患者也会出现高血压。然而，任何遗传关系似乎都被忽视了。在旨在防止肾皮质侧支循环发展的实验过程中，尝试了玻璃纸，因为人们认为它对组织造成的损害很小。很快就发现，用玻璃纸包裹肾脏的动物出现了动脉高血压。检查显示它们被包裹在3至4 mm厚的纤维胶原船体内。玻璃纸已经破碎，主要被网膜吸收。肾脏在被切开时从船体上隆起，表明在张力下实质被紧紧地抓住。组织对玻璃纸的反应非同寻常。接触相对较短的时间（3 ~ 30天）就足以引起增殖反应，至少在玻璃纸被网膜分散后，增殖反应会持续一段时间。
Perinephritis apparently has not been recognized as a possible cause of arterial hypertension. Occasionally hypertension has been recorded for patients whose renal parenchyma from one cause or another has been chronically compressed. Any genetic relationship seems, however, to have been ignored. During the course of experiments designed to prevent the development of renal cortical collateral circulation, cellophane was tried because it was believed that it would cause little damage to the tissues. It was soon apparent that arterial hypertension had developed in the animals in which cellophane had been wrapped around the kidneys. Examination showed them to be enclosed within a fibrocollagenous hull from 3 to 4 mm. thick. The cellophane had been fragmented and taken up, chiefly by the omentum. The kidney bulged from the hull when it was cut, indicating that the parenchyma was held fast under tension. The reaction of tissue to cellophane is extraordinary. Contact for relatively short periods (three to thirty days) is enough to evoke a proliferative reaction which continues for a time, at least, after the cellophane has been dispersed by the omentum.