Copper-catalyzed domino addition/double cyclization: an approach to polycyclic benzimidazole derivatives.
Copper-catalyzed domino addition/double cyclization: an approach to polycyclic benzimidazole derivatives.
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DOI：
10.1021/jo402742k
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发表时间：
2014-02
期刊：
影响因子：
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通讯作者：
Guodong Yuan;Haiquan Liu;Jilong Gao;Kangjian Yang;Qingsheng Niu;H. Mao;Xiaoxia Wang;Xin Lv
中科院分区：
文献类型：
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作者：
Guodong Yuan;Haiquan Liu;Jilong Gao;Kangjian Yang;Qingsheng Niu;H. Mao;Xiaoxia Wang;Xin Lv
An efficient and versatile method for the assembly of novel polycyclic benzimidazole derivatives has been developed by Cu-catalyzed domino addition/double cyclization reactions. A wide variety of polycyclic benzimidazole derivatives, which might be used as synthetic medicines and functional materials, were successfully assembled from bis-(o-haloaryl)carbodiimides. Unexpected N-methylated benzo[4,5]imidazo[1,2-a]indoles can also be selectively assembled. Multibonds and polycyclic moieties were conveniently formed in one pot during these domino processes.
