Histamine-induced arousal in the conscious and pentobarbital-pretreated rat.
Histamine-induced arousal in the conscious and pentobarbital-pretreated rat.
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组胺在清醒和戊巴比妥预处理的大鼠中引起的唤醒。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
P. Kalivas
中科院分区：
文献类型：
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作者：
P. Kalivas
组胺已被证明具有许多神经递质样特性，各种研究表明中枢组胺可能在调节行为唤醒中起作用。为了进一步检验这种可能性，将组胺注入清醒和戊巴比妥麻醉的大鼠的侧脑室。在有意识的动物中，与盐水处理的对照组相比，组胺诱导自发运动活动的显著增加，包括增加梳理和探索行为（嗅探，饲养和运动）。在戊巴比妥预处理的大鼠中，组胺导致麻醉持续时间和体温过低的剂量相关减少，而不改变戊巴比妥在大脑或血浆中的分布。给药结构上与组胺相关的化合物不会改变自发活动或缩短麻醉持续时间。虽然用h2 -组胺拮抗剂西咪替丁预处理无效，但发现h1 -组胺拮抗剂可以消除组胺诱导的觉醒。氟哌啶醇在显著减弱安非他明引起的自发运动活动的剂量下，并没有改变组胺诱导的多动。同样，阿托品没有显著改变组胺诱导的觉醒。这些数据支持了组胺可能在调节行为唤醒中起作用的假设。
Histamine has been shown to possess many neurotransmitter-like properties, and a variety of studies indicate that central histamine may function in modulating behavioral arousal. To examine this possibility further, histamine was administered into the lateral cerebral ventricles of the conscious and pentobarbital-anesthetized rat. In the conscious animal, histamine induced a significant increase in spontaneous motor activity which consisted of increased grooming and exploratory behaviors (sniffing, rearing and locomotion) as compared to saline-treated controls. In the pentobarbital-pretreated rat, histamine caused a dose-related decrease in narcosis duration and hypothermia without altering the disposition of pentobarbital in brain or plasma. Administration of compounds structurally related to histamine did not alter spontaneous activity or shorten narcosis duration. While pretreatment with the H2-histamine antagonist, cimetidine, was no effective, H1-histamine antagonists were found to abolish histamine-induced arousal. Administration of haloperidol in doses that significantly attenuated increased spontaneous motor activity by amphetamine did not alter histamine-induced hyperactivity. Likewise, atropine did not significantly alter histamine-induced arousal. These data support the hypothesis that histamine may function in modulating behavioral arousal.