Exploring generalisation processes following lexical retrieval intervention in primary progressive aphasia
Exploring generalisation processes following lexical retrieval intervention in primary progressive aphasia
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DOI：
10.3109/17549507.2016.1151936
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发表时间：
2016-01-01
影响因子：
1.8
通讯作者：
Panegyres, Peter K.
中科院分区：
文献类型：
--
作者：
Beales, Ashleigh;Cartwright, Jade;Panegyres, Peter K.
目的：在目前的文献中，积极的干预效果表明，原发性进行性失语症(PPA)患者学习/重新学习单词具有显著的潜力。然而，干预效应对其他词和/或其他语境的概括仍然不清楚。方法：这个多基线的案例系列设计考察了跨词类(名词、动词和形容词)的自我线索词汇提取干预对四个PPA个体的影响，其中三个个体暗示了语义变体，一个个体暗示了对数变体。这项干预综合了语言产生的语义、语音和正字法水平，并利用了自传体记忆。使用Cochran‘s Q测验和后续的McNemar配对比较，确定在提取已处理和未处理物品(干预前、干预后和4周维护)的准确性方面的变化。结果：所有参与者在命名已处理物品时，在所有词类中都有显著的改善。研究发现，每个参与者对未经处理的单词有不同的综合改进模式。在语篇中，语义变异者的正确信息单位显著增加，而对数变异者保持稳定。结论：本研究为PPA患者在干预后词汇提取能力的提高提供了证据。这些发现表明，不同的词类和潜在的缺陷在概括上可能存在差异。
Purpose: Within the current literature, positive intervention effects demonstrate the significant potential for people with Primary Progressive Aphasia (PPA) to learn/relearn words. Generalisation of intervention effects to other words and/or other contexts, however, remains unclear.Method: This multiple baseline, case-series design investigated the effects of a self-cueing lexical retrieval intervention across word classes (nouns, verbs and adjectives) on four individuals with PPA, three suggestive of the semantic variant and one of the logopenic variant. The intervention integrated semantic, phonological and orthographic levels of language production and drew on autobiographical memory. Changes in accuracy in retrieving treated and untreated items (pre-intervention, post-intervention and 4-weeks maintenance) were determined using the Cochran's Q test, with follow-up McNemar pairwise comparisons.Result: All participants showed significant improvements in naming treated items, across all word classes. Different patterns of generalised improvement to untreated words were found for each participant. In discourse, the semantic variant participants demonstrated a significant increase in correct information units, in contrast to the participant with the logopenic variant who remained stable.Conclusion: This study provides evidence that people with PPA can show improved lexical retrieval following intervention. The findings suggest possible differences in generalisation across word classes and according to underlying deficit.