Neurobehavioral effects of HIV-1 infection in china and the united states: A pilot study
Neurobehavioral effects of HIV-1 infection in china and the united states: A pilot study
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DOI：
10.1017/s1355617707071007
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发表时间：
2007-09-01
影响因子：
2.6
通讯作者：
Heaton, Robert K.
中科院分区：
文献类型：
--
作者：
Cysique, Lucette A.;Jin, Hua;Heaton, Robert K.
艾滋病毒在中国的流行呈指数级增长，但目前还没有关于该国艾滋病毒感染的神经行为影响的研究。大多数神经艾滋病研究在西方国家使用西方神经心理学（NP）方法进行，目前尚不清楚这些测试方法是否适合在中国使用。28名HIV血清阳性（HIV+）和23名HIV血清阴性（HIV-）个体，性别相当。的年龄。教育分布在北京和中国安徽农村。从圣地亚哥HIV神经行为研究中心招募的一个更大的美国队列中选择了39名HIV+和31名HIV-个体，在年龄、疾病状态和治疗变量方面与中国样本相匹配。在美国和中国的队列中使用的NP测试组包括在美国广泛用于研究HIV感染的仪器。它由14个单独的测试组成，每个测试被分配到七个被认为特别容易受到艾滋病毒影响的能力区域中的一个（即语言流畅性、抽象/执行功能、信息处理速度、工作记忆、学习、延迟回忆和运动功能）。为了探讨NP测量的跨文化等价性和有效性，我们比较了中国和美国样本的个人测试，以及总容量和七个能力域的平均量表得分。在各NP测试中，中国HIV+组的平均值低于HIV组。一系列涉及两国HIV+和HIV-组的2x2方差分析显示，HIV对全球和所有领域平均量表得分的影响非常显著。国家的影响出现在两个个人能力领域，至少部分是由于两国之间的教育差异。重要的是，缺乏国别间的相互作用表明，艾滋病毒的NP效应在这两个国家是相似的。在中国HIV研究中使用的NP测试似乎具有良好的跨文化等效性，但需要适当的中国规范来识别个体中国人的疾病相关损害。为了为这些规范的制定提供信息，需要对人口影响进行更大规模的研究。特别是考虑到那个国家的教育范围很广。
The HIV epidemic in China has been increasing exponentially, yet there have been no studies of the neurobehavioral effects of HIV infection in that country. Most neuroAIDS research has been conducted in Western countries using Western nellropsychological (NP) methods, and it is unclear whether these testing methods are appropriate for use in China. Twenty-eight HIV seropositive (HIV+) and twenty-three HIV seronegative (HIV-) individuals with comparable gender. age. and education distributions were recruited in Beijing and the rural Anhui province in China. Thirty-nine HIV+ and thirty-one HIV- individuals were selected from a larger U.S. cohort recruited at the HIV Neurobehavioral Research Center, in San Diego, to be matched to the Chinese sample for age, disease status, and treatment variables. The NP test battery used with the U.S. and China cohorts included instruments widely used to study HIV infection in the United States. It consisted of 14 individual test measures, each assigned to one of seven ability areas thought to be especially vulnerable to effects of HIV oil the brain (i.e., verbal fluency, abstraction/executive function, speed of information processing, working memory, learning, delayed recall, and motor function). To explore the cross-cultural equivalence and validity of the NP measures, we compared our Chinese and U.S. samples on the individual tests, as well as mean scaled scores for the total battery and seven ability domains. On each NP test measure, the mean of the Chinese HIV+ group was worse than that of the HIV-group. A series of 2 X 2 analyses of variance involving HIV+ and HIV- groups from both countries revealed highly significant HIV effects on the Global and all Domain mean scaled scores. Country effects appeared on two of the individual ability areas, at least partly due to education differences between the two countries. Importantly, the absence of HIV-by-Country interactions suggests that the NP effects of HIV are similar in the two countries. The NP test battery that was chosen and adapted for use in this study of HIV in China appears to have good cross-cultural equivalence, but appropriate Chinese norms will be needed to identify disease-related impairment in individual Chinese people. To inform the development of such norms, a much larger study of demographic effects will be needed. especially considering the wide range of education in that country.