Dietary factors related to higher plasma fibrinogen levels of Japanese-Americans in Hawaii compared with Japanese in Japan
Dietary factors related to higher plasma fibrinogen levels of Japanese-Americans in Hawaii compared with Japanese in Japan
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DOI：
10.1161/01.atv.0000225701.20965.b9
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发表时间：
2006-07-01
影响因子：
8.7
通讯作者：
Stamler, Jeremiah
中科院分区：
文献类型：
--
作者：
Miura, Katsuyuki;Nakagawa, Hideaki;Stamler, Jeremiah
目的--我们调查了在夏威夷过着西方生活方式的日本移民血浆纤维蛋白原水平高于在日本的日本移民的饮食因素。方法和结果-从夏威夷的日裔美国人样本(100名男性和106名女性)和4名日本人群(569名男性和567名女性)的40-59岁的男性和女性的血浆纤维蛋白原和营养素摄入量的标准化方法进行了检测。用多元线性回归模型检验饮食因素与夏威夷和日本血浆纤维蛋白原差异的关系。夏威夷的平均血浆纤维蛋白原显著高于日本(P<；男女均为0.001)。在单独考虑每个饮食变量的多元线性回归分析中，体重指数使夏威夷和日本之间的血浆纤维蛋白原差异减少了20.4%，铁摄入量(mg/1000千卡)和估计总糖摄入量(%千卡)分别使这种差异减少了30.0%和14.4%。在一个包括体重指数、铁、估计总糖和咖啡因(也包括年龄和性别)的模型中，这一差异减少了61.3%(从42.2 mg/dL减少到16.3 mg/dL)。结论-除了肥胖外，铁、糖和咖啡因的更高摄入量是西方人生活方式较高的纤维蛋白原水平的主要原因。
Objective - We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan.Methods and Results - Plasma fibrinogen and nutrient intakes were examined by standardized methods in men and women 40 to 59 years of age from a Japanese-American sample in Hawaii ( 100 men and 106 women) and 4 population samples in Japan ( 569 men and 567 women). Multiple linear regression models were used to examine the relationship between dietary factors and the plasma fibrinogen difference between Hawaii and Japan. Average plasma fibrinogen was significantly higher in Hawaii compared with Japan (P < 0.001 in both genders). In multiple linear regression analyses with each dietary variable considered separately, body mass index reduced the plasma fibrinogen difference between Hawaii and Japan by 20.4%; iron intake (mg/1000 kcal) and estimated total sugar intake (% kcal) reduced this difference by 30.0% and 14.4%, respectively. In a model that included body mass index, iron, estimated total sugars, and caffeine ( also age and gender), this difference was reduced by 61.3% ( from 42.2 to 16.3 mg/ dL).Conclusions - Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle.