New sesquiterpene hydroquinones from a Taiwanese marine sponge, Hippospongia metachromia
New sesquiterpene hydroquinones from a Taiwanese marine sponge, Hippospongia metachromia
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DOI：
10.1021/np000610c
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发表时间：
2001-06-01
影响因子：
5.1
通讯作者：
Kuo, YH
中科院分区：
文献类型：
--
作者：
Shen, YC;Chen, CY;Kuo, YH
从异染海海绵Hippospongia metachromia中分离得到两个新的倍半萜类化合物：异染绿素A（1），异染绿素B（2），异染绿素E（9），异染绿素A和异染绿素B（3，4）。4-6的结构通过广泛的2D NMR分析确定。异染色质A（1）和B（2）、异染色质A二乙酸酯（5）和异染色质B单乙酸酯（8）对人结肠（科洛-205）和鼻咽（KB）肿瘤细胞表现出强的细胞毒性，而化合物6、7和9无活性。
In addition to metachromins A (1), B (2), and E (9), two new sesquiterpene hydroquinones, hippochromins A and B (3, 4), were isolated from the Taiwanese marine sponge Hippospongia metachromia. The structures of 4-6 were established by extensive 2D NMR analysis. Metachromins A (1) and B (2), hippochromin A diacetate (5), and metachromin B monoacetate (8) exhibited potent cytotoxicities against human colon (COLO-205) and nasopharyngeal (KB) tumor cells, while compounds 6, 7, and 9 were inactive.