Collagen cross-linking alterations in joint contractures: changes in the reducible cross-links in periarticular connective tissue collagen after nine weeks of immobilization.
Collagen cross-linking alterations in joint contractures: changes in the reducible cross-links in periarticular connective tissue collagen after nine weeks of immobilization.
复制标题
关节挛缩中胶原蛋白交联的改变：固定九周后关节周围结缔组织胶原中可还原交联的变化。
DOI：
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发表时间：
1977
影响因子：
2.9
通讯作者：
Michelle Hamer
中科院分区：
文献类型：
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作者：
Wayne H. Akeson;David Amiel;G. Mechanic;S. Woo;F. Harwood;Michelle Hamer
在9周固定兔关节周围结缔组织中发现NaBH4可还原的分子间交联显著增加。二羟基赖氨酸氨基去亮氨酸、羟基赖氨酸氨基去亮氨酸和组氨酸二羟基去亮氨酸是主要的交联，在固定化期间增加。在兔膝关节强制固定9周期间，固定组与对照组关节周围结缔组织胶原的羟基赖氨酸/赖氨酸比值未见变化。由于固定关节周围结缔组织中的胶原蛋白质量没有改变，最多减少10%，我们认为由于缺乏身体压力和运动，胶原蛋白交联增加，以胶原蛋白单位重量和每膝关节胶原蛋白质量表示。
A significant increase in the NaBH4 reducible intermolecular cross-links in the 9 week immobilized rabbit periarticular connective tissue was found. Dihydroxylysinonorleucine, hydroxylysinonorleucine, and histidinohydroxymerodesmosine were the major cross-links which increased during the period of immobilization. No change in the hydroxlysine/lysine ratio between the immobilized and control periarticular connective tissue collagen was detected during the 9 weeks of enforced immobilization of the rabbit knee. Since the collagen mass in the immobilized periarticular connective tissue does not change, or at most is reduced 10%, we suggest that there is an increase in collagen cross-links expressed both in per unit weight of collagen and on the basis of collagen mass per knee due to the lack of physical stress and motion.