CONNECTIONS OF AREA-8 WITH AREA-6 IN THE BRAIN OF THE MACAQUE MONKEY
CONNECTIONS OF AREA-8 WITH AREA-6 IN THE BRAIN OF THE MACAQUE MONKEY
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DOI：
10.1002/cne.902770103
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发表时间：
1988-11-01
影响因子：
2.5
通讯作者：
KUBOTA, K
中科院分区：
文献类型：
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作者：
ARIKUNI, T;WATANABE, K;KUBOTA, K
使用麦芽凝集素缀合辣根过氧化物酶 (WGA-HRP) 对猕猴大脑中的弓状区（沃克区 8A 和 45 或布罗德曼区 8）与前运动区和辅助运动区（福格茨区 6）之间的皮质连接进行了显微镜研究，该酶被注射到布罗德曼区 8，主要是为了阐明区域 8 到区域 6 的投影。此外，在同一材料中，研究了前额叶皮层的弓形区域和区域 46 之间的连接模式。根据本研究的结果，讨论了 8、6 和 46 区的解剖皮质层次。顺行标记细胞出现在运动前区、辅助运动区和注射侧46区；含有标记轴突末端的位点也含有标记细胞。换句话说，所检查的联系是相互的。在标记区域中，标记端子和细胞共存，并且大多数形成放射状柱。然而，在运动区（布罗德曼区 4）没有看到细胞和末端的标记。将WGA-HRP注射到8A区后；标记的末端和细胞主要出现在上运动前区（弓状刺上方的运动前区区域，Vogt 和 Vogt 的上部区域 6a.alpha. 和 (6.β.)，在前后方向上形成一个、两个或三个标记带，而标记在下运动前区（弓状刺下方的运动前区区域，Vogt 和 Vogt' 的区域 4c，下部）出现较少程度。相比之下，将WGA-HRP注射到区域45导致了运动前区的主要标记，而运动前区的标记很少，尽管在第三层的下半部发现了很少的标记细胞，并且标记的细胞主要分布在前额皮质主沟的区域46中。在所有皮质层或整个皮质深度中，IV层中标记细胞浓度较低；主要在III层和V层中发现，V层中密度相对较高。
The corticocortical connections between the arcuate area (Walker''s areas 8A and 45 or Brodmann''s area 8) and the premotor and supplementary motor areas (Vogts'' area 6) in the brain of the macaque monkey were studied microscopically with wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP), which was injected into Brodmann''s area 8 primarily to elucidate the projections of area 8 into area 6. In addition, in the same material, the pattern of connections between the arcuate area and area 46 of the prefrontal cortex was studied. On the basis of the findings of the present study, and anatomical cortical hierarchy for areas 8, 6, and 46 is discussed. Anterogradely labeled cells appeared in the premotor area, in the supplementary motor area, and in area 46 on the side of injection; sites containing labeled axon terminals also contained labeled cells. In other words, the examined connections were reciprocal. In the labeled areas, labeled terminals and cells coexisted, and most formed radial columns. However, no labelling of cells and terminals was seen in the motor area (Brodmann''s area 4). After injection of WGA-HRP into area 8A; labeled terminals and cells appeared predominantly in the superior premotor area (a region of the premotor area above the arcuate spur, Vogt and Vogt''s upper areas 6a.alpha. and (6.beta.), forming one, two or three bands of label in the anteroposterior direction, whereas labeling occurred to a lesser extent in the inferior premotor area (a region of the premotor area below the arcuate spur, Vogt and Vogt''s areas 4c, lower 6a.alpha. and 6b). In contrast, injection of WGA-HRP into area 45 resulted in the predominant labeling of the inferior premotor area with scant labeling in the superior premotor area. In the premotor area, labeled terminals were distributed over the entire cortical depth, although few were found in the lower half of layer III, and labeled cells were distributed mainly in layer III. In area 46 of the banks of the principal sulcus in the prefrontal cortex, labeled terminals were distributed in all cortical layers or over the entire cortical depth with a lower concentration in layer IV; labeled cells were found mostly in layers III and V, with a relatively high density in layer V.