Computational study of growth and remodelling in the aortic arch
Computational study of growth and remodelling in the aortic arch
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DOI：
10.1080/10255840801930710
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发表时间：
2008-01-01
影响因子：
1.6
通讯作者：
Taber, Larry A.
中科院分区：
文献类型：
--
作者：
Alford, Patrick W.;Taber, Larry A.
开角（OA）与动脉的生长和重塑有关。令人好奇的是，在一些动物的主动脉弓中发现了相对较大的OAs。在这里，我们使用计算模型来探索这一现象背后的原因。假设动脉包含平滑肌/胶原蛋白相和弹性蛋白相。在模型中，平滑肌/胶原的生长和重塑取决于壁应力和流体剪切应力。弹性蛋白的重塑通常非常缓慢，被忽略了。结果表明，OAs一般增加纵向曲率（环面模型），早期弹性蛋白生产过程中的发展，并降低壁刚度。将这些结果与现有的实验数据相关联表明，所有这些影响可能有助于在主动脉弓中的大OAs。模型还表明，弹性蛋白的缓慢周转率限制了纵向生长。这些结果将促进对动脉中残余应力原因的了解。
Opening angles (OAs) are associated with growth and remodelling in arteries. One curiosity has been the relatively large OAs found in the aortic arch of some animals. Here, we use computational models to explore the reasons behind this phenomenon. The artery is assumed to contain a smooth muscle/collagen phase and an elastin phase. In the models, growth and remodelling of smooth muscle/collagen depends on wall stress and fluid shear stress. Remodelling of elastin, which normally turns over very slowly, is neglected. The results indicate that OAs generally increase with longitudinal curvature (torus model), earlier elastin production during development, and decreased wall stiffness. Correlating these results with available experimental data suggests that all of these effects may contribute to the large OAs in the aortic arch. The models also suggest that the slow turnover rate of elastin limits longitudinal growth. These results should promote increased understanding of the causes of residual stress in arteries.