Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines
Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines
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DOI：
10.1016/s0889-1591(03)00029-1
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发表时间：
2003-10-01
影响因子：
15.1
通讯作者：
Steptoe, A
中科院分区：
文献类型：
--
作者：
Kunz-Ebrecht, SR;Mohamed-Ali, V;Steptoe, A
糖皮质激素可以下调免疫活性，但据报道，急性应激会增加皮质醇和血浆细胞因子的水平。我们研究了皮质醇反应的个体差异及其与促炎细胞因子的关系，如白细胞介素-6 （IL-6）、白细胞介素-1受体拮抗剂（IL-1ra）、心血管活动和心理健康。研究人员从白厅11号队列的199名健康中年参与者中提取了唾液和血液样本，分别在压力刚结束时和45分钟后采集。我们将对压力皮质醇反应最高的40%的参与者定义为皮质醇反应组，将反应最低的40%的参与者定义为皮质醇无反应组。皮质醇无反应组血浆IL-6升高，IL-1ra对应激的反应更大。皮质醇无反应者的心率变异性低于皮质醇反应者。皮质醇反应组在任务中经历了更多的主观压力，并报告了比无反应组更多的心理健康受损。我们的结论是，神经内分泌应激反应的个体差异可能对促炎细胞因子有影响，高和低皮质醇应激反应都有潜在的不利影响。(C) 2003 Elsevier Science（美国）版权所有。
Glucocorticoids can down-regulate immune activity, but acute stress has been reported to increase both cortisol and levels of plasma cytokines. We investigated individual differences in cortisol responses and their associations with proinflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), cardiovascular activity, and mental health. Saliva samples and blood were taken from 199 healthy middle-aged participants of the Whitehall 11 cohort at baseline, immediately after stress and 45 min later. We defined the 40% of participants with the highest cortisol response to stress as the cortisol responder group and 40% with the lowest response as the cortisol non-responder group. Plasma IL-6 was higher and the IL-1ra response to stress was greater in the cortisol non-responder group. The cortisol non-responders showed lower heart rate variability than the cortisol responders. The cortisol responder group experienced more subjective stress during the tasks and reported more impaired mental health than the non-responders. We conclude that individual variations in neuroendocrine stress responsivity may have an impact on proinflammatory cytokines, and that both high and low cortisol stress responsiveness has potentially adverse effects. (C) 2003 Elsevier Science (USA). All rights reserved.