Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange
Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange
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DOI：
10.1097/mej.0b013e32830a7567
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发表时间：
2009-02-01
影响因子：
4.4
通讯作者：
Yuksel, Sinemis
中科院分区：
文献类型：
--
作者：
Turkcuer, Ibrahim;Erdur, Bulent;Yuksel, Sinemis
目的探讨大剂量二甲双胍过量合并乳酸酸中毒的治疗方法。病例报告1例30岁女性，口服85g大剂量二甲双胍后合并严重乳酸酸中毒，自杀未遂，采用碳酸氢盐和血浆置换进行长期血液透析治疗。结论为最大限度地消除二甲双胍，延长血液透析时间，增加碳酸氢盐对伴随代谢性酸中毒患者的治疗效果。《欧洲急诊医学杂志》16：11-13(C)2009，Wolters Kluwer Health，竖条，Lippincott Williams&Wilkins。
Background Biguanides pose a significant risk of morbidity, mortality and permanent sequelae secondary to prolonged periods of hypoglycaemia.Objectives To investigate the treatment of massive metformin overdose associated with lactic acidosis.Case report We present the case of a 30-year-old woman, who attempted to commit suicide by ingesting an 85-g massive metformin overdose associated with severe lactic acidosis, which we treated by performing prolonged haemodialysis with bicarbonate and plasma exchange.Conclusion For the maximum elimination of metformin, extended haemodialysis is required and the treatment of the accompanying metabolic acidosis with bicarbonate is important for the effectiveness of the treatment.Patients benefit much more from the treatment of combined haemodialysis with plasma exchange. European Journal of Emergency Medicine 16:11-13 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.