NK Cell Exhaustion.
NK Cell Exhaustion.
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NK 细胞耗竭。
DOI：
10.3389/fimmu.2017.00760
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发表时间：
2017
影响因子：
7.3
通讯作者：
Tian Z
中科院分区：
文献类型：
--
作者：
Bi J;Tian Z
自然杀伤细胞是天然免疫系统中重要的效应淋巴细胞，在抗肿瘤和抗感染宿主防御中起重要作用。然而，肿瘤进展或慢性感染通常导致NK细胞耗尽，从而限制了NK细胞的抗肿瘤/感染潜力。在许多肿瘤或慢性感染中，多种机制可能导致NK细胞耗竭，例如NK细胞受体信号传导失调，以及微环境中调节细胞或可溶性因子的抑制作用。更好地了解NK细胞耗竭的特征以及潜在机制，不仅可以增加我们对NK细胞基本生物学的理解，还可以揭示新的基于NK细胞的抗肿瘤/感染靶点。在这里，我们提供了一个概述，我们目前的知识NK细胞耗竭肿瘤，慢性感染。
Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustion of NK cells, such as dysregulated NK cell receptors signaling, as well as suppressive effects by regulatory cells or soluble factors within the microenvironment. Better understanding of the characteristics, as well as the underlying mechanisms of NK cell exhaustion, not only should increase our understanding of the basic biology of NK cells but also could reveal novel NK cell-based antitumor/infection targets. Here, we provide an overview of our current knowledge on NK cell exhaustion in tumors, and in chronic infections.