Treatment of patients with peritoneal metastases from gastric cancer.
Treatment of patients with peritoneal metastases from gastric cancer.
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DOI：
10.1002/ags3.12060
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发表时间：
2018-03
影响因子：
2.7
通讯作者：
Sata N
中科院分区：
文献类型：
--
作者：
Kitayama J;Ishigami H;Yamaguchi H;Sakuma Y;Horie H;Hosoya Y;Lefor AK;Sata N
尽管最近化疗取得了进展，但胃癌腹膜转移（PM）患者的结局仍然很差，标准治疗尚未建立。虽然口服S-1似乎对PM患者有效，但全身化疗的效果有限。与其他恶性肿瘤PM患者相比，胃癌PM患者行细胞减灭术（CRS）和腹腔热化疗（HIPEC）的获益较少。相比之下，使用植入式腹膜输液港的紫杉烷重复腹膜内化疗（RIPEC）在控制腹膜病变方面具有药代动力学优势，与全身化疗联合使用可使胃癌PM患者获得令人惊讶的长期生存。在此，我们回顾了最近专门针对胃癌PM的临床研究结果，并讨论了腹膜内方法对胃癌腹膜受累患者理想治疗的未来前景。
Despite recent advances in chemotherapy, outcomes of patients with peritoneal metastases (PM) from gastric cancer are still very poor and standard treatment has not been established. Although oral S‐1 appears to be effective for patients with PM, the effects of systemic chemotherapy are limited. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) yield fewer benefits in patients with PM from gastric cancer than in patients with PM from other malignancies. In comparison, repeated intraperitoneal chemotherapy (RIPEC) with taxanes using an implantable peritoneal access port has a pharmacokinetic advantage for the control of peritoneal lesions and in combination with systemic chemotherapy can result in surprisingly long‐term survival in patients with PM from gastric cancer. Herein, we review the results of recent clinical studies specifically targeting PM from gastric cancer and discuss future prospects for an intraperitoneal approach to the ideal treatment of patients with gastric cancer with peritoneal involvement.
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作者：
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