A PROSPECTIVE-STUDY OF ASPIRIN USE AND CATARACT-EXTRACTION IN WOMEN
A PROSPECTIVE-STUDY OF ASPIRIN USE AND CATARACT-EXTRACTION IN WOMEN
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DOI：
10.1001/archopht.1993.01090040095040
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发表时间：
1993-04-01
影响因子：
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通讯作者：
WILLETT, WC
中科院分区：
文献类型：
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作者：
HANKINSON, SE;SEDDON, JM;WILLETT, WC
我们在一项针对女性的大型前瞻性研究——护士健康研究中，在 8 年的随访期间检查了阿司匹林使用与白内障摘除率之间的关联。从 1980 年到 1988 年，我们在 434680 人年的随访中记录了 448 例老年性白内障的诊断和摘除。虽然我们在年龄调整分析中观察到较高剂量的阿司匹林使用存在适度的正相关性，但在考虑其他白内障风险因素后，没有发现任何相关性（使用大于或等于 20 年的相对风险为 1.08；95% 置信区间为 0.84 至 1.39）。对于连续 20 年或更长时间内每周服用 7 片或更多片剂的女性，没有任何保护作用的建议；如果说有什么不同的话，那就是观察到风险不显着升高（相对风险，1.31；95% 置信区间，0.94 至 1.80）。当按年龄评估时，我们观察到阿司匹林使用与白内障之间的关系没有一致的差异。总体而言，我们没有发现任何证据支持阿司匹林使用者的白内障风险大幅降低，正如之前几项研究报告的那样。
We examined the association between aspirin use and the rates of cataract extraction during 8 years of follow-up in a large prospective study of women, the Nurses' Health Study. From 1980 to 1988, we documented 448 senile cataracts diagnosed and extracted during 434680 person-years of follow-up. While we observed a modest positive association at the higher doses of aspirin use in the age-adjusted analyses, no association was found after accounting for other cataract risk factors (relative risk for greater-than-or-equal-to 20 years of use, 1.08; 95% confidence interval, 0.84 to 1.39). Among women who consumed seven or more tablets per week for 20 or more years, there was no suggestion of protection; if anything, a non-significantly elevated risk was observed (relative risk, 1.31; 95% confidence interval, 0.94 to 1.80). We observed no consistent difference in the relationship between aspirin use and cataract when assessed by age. Overall, we found no evidence to support the substantial reduction in risk of cataract among aspirin users as reported in several previous studies.