Cutting edge: The dendritic cell cytoskeleton is critical for the formation of the immunological synapse
Cutting edge: The dendritic cell cytoskeleton is critical for the formation of the immunological synapse
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DOI：
10.4049/jimmunol.166.3.1452
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发表时间：
2001-02-01
影响因子：
4.4
通讯作者：
West, KA
中科院分区：
文献类型：
--
作者：
Al-Alwan, MM;Rowden, G;West, KA
T细胞与APC的结合导致T细胞肌动蛋白细胞骨架重排，从而形成免疫突触。APC细胞骨架被认为在这一过程中扮演了被动的角色。在这项研究中，我们证明了树突状细胞(DC)与其他APC不同，在与T细胞相互作用的过程中，会主动极化其肌动蛋白细胞骨架。DC细胞骨架重排对于静息T细胞的聚集和激活都是至关重要的。这项研究提供了令人信服的证据，表明APC细胞骨架在免疫突触中发挥着积极的作用，并可能解释DC激活静止T细胞的独特能力。
The binding of a T cell to an APC results in T cell actin cytoskeletal rearrangement leading to the formation of an immunological synapse. The APC cytoskeleton has been thought to play a passive role in this process. In this study, we demonstrate that dendritic cells (DC), unlike other APC, actively polarize their actin cytoskeleton during interaction with T cells. DC cytoskeletal rearrangement was critical for both the clustering and the activation of resting T cells. This study provides compelling evidence that the APC cytoskeleton plays an active role in the immunological synapse and may explain the unique ability of DC to activate resting T cells.