Anti‐endotoxin immunotherapy for canine parvovirus endotoxaemia
Anti‐endotoxin immunotherapy for canine parvovirus endotoxaemia
复制标题
抗内毒素免疫治疗犬细小病毒内毒素血症
DOI：
10.1111/j.1748-5827.1986.tb03760.x
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发表时间：
1986
影响因子：
1.6
通讯作者：
S. Gaffin
中科院分区：
文献类型：
--
作者：
B. Wessels;S. Gaffin
The morbidity and mortality associated with canine parvovirus disease (CPV) is caused, in part, by endotoxin (LPS). Equine anti-endotoxin hyperimmune plasma (Anti-LPS) was administered to 89 CPV patients in addition to conventional therapy. In Anti-LPS treated CPV patients mortality was lower (16-8 per cent, 15/89) than in controls that received conventional therapy alone (66-7 per cent, 24/36, P < 0–0005). The hospitalization period of survivors was reduced from 8-5 ± 4-0 days (controls) to 5-2 ± 2-0 days (Anti-LPS treated group). These results suggest that an anti-endotoxin specific therapy should be incorporated into the treatment regimen of CPV, and possibly, other canine enteric disorders, known to produce endotoxaemia.
