The chemical biology of hydropersulfides (RSSH): Chemical stability, reactivity and redox roles.
The chemical biology of hydropersulfides (RSSH): Chemical stability, reactivity and redox roles.
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DOI：
10.1016/j.abb.2015.10.016
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发表时间：
2015-12-15
影响因子：
3.9
通讯作者：
Fukuto JM
中科院分区：
文献类型：
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作者：
Saund SS;Sosa V;Henriquez S;Nguyen QN;Bianco CL;Soeda S;Millikin R;White C;Le H;Ono K;Tantillo DJ;Kumagai Y;Akaike T;Lin J;Fukuto JM
最近的报告表明，在哺乳动物系统中普遍存在的氢过硫化物（RSSH）。这些物种和相关物种的生物用途目前是一个重要的猜测。过硫氢化合物的功能、寿命和归宿将取决于其化学性质和反应活性。因此，作为进一步的机制研究的基础，关于过氧化氢生物学，一些基本的化学性质/反应性的过氧化氢进行了研究。在生物条件下考察了过硫化物的亲核性、亲电性和氧化还原性。这些研究表明，氢过硫化物可以是亲核或亲电的，这取决于pH值（即质子化状态），可以作为良好的单电子和双电子还原剂。这些不同的化学性质在一个单一的物种，使氢过硫化物化学上不同于其他，众所周知的含硫生物物种，给他们独特的和潜在的重要的生物功能。
Recent reports indicate the ubiquitous prevalence of hydropersulfides (RSSH) in mammalian systems. The biological utility of these and related species is currently a matter of significant speculation. The function, lifetime and fate of hydropersulfides will be assuredly based on their chemical properties and reactivity. Thus, to serve as the basis for further mechanistic studies regarding hydropersulfide biology, some of the basic chemical properties/reactivity of hydropersulfides were studied. The nucleophilicity, electrophilicity and redox properties of hydropersulfides were examined under biological conditions. These studies indicate that hydropersulfides can be nucleophilic or electrophilic, depending on the pH (i.e. the protonation state) and can act as good one- and two-electron reductants. These diverse chemical properties in a single species make hydropersulfides chemically distinct from other, well-known sulfur containing biological species, giving them unique and potentially important biological function.