Peripheral nerves in the tibial subchondral bone : the role of pain and homeostasis in osteoarthritis.
Peripheral nerves in the tibial subchondral bone : the role of pain and homeostasis in osteoarthritis.
复制标题
胫骨软骨下骨的周围神经：疼痛和体内平衡在骨关节炎中的作用
DOI：
10.1302/2046-3758.117.bjr-2021-0355.r1
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发表时间：
2022-07
影响因子：
4.6
通讯作者：
Cai, M.
中科院分区：
文献类型：
--
作者：
Sun, Q.;Li, G.;Liu, D.;Xie, W.;Xiao, W.;Li, Y.;Cai, M.
骨关节炎是一种非常普遍的退行性关节疾病，以关节疼痛和身体残疾为特征。软骨下骨的异常可引起病理改变，是骨性关节炎疼痛的主要原因。在高度神经支配的软骨下骨中，神经在痛觉和骨内稳态调节中具有双重作用。周围神经和软骨下骨靶细胞之间的相互作用，以及感觉和交感神经系统之间的相互作用，使周围神经能够调节软骨下骨的动态平衡。周围神经和局部递质的改变与伤害性感觉和软骨下骨稳态的改变密切相关，并影响骨性关节炎的进展。最近的文献极大地扩展了我们对骨骼中特定亚型神经元的生理、病理分布和功能的理解。本文综述了在胫骨软骨下骨中发现的神经的类型和分布，它们与调节软骨下骨内稳态的骨细胞的细胞和分子相互作用，以及它们在骨性关节炎疼痛中的作用。全面了解和深入研究软骨下骨外周神经支配的功能，将有助于开发新的治疗方法，有效预防骨性关节炎，缓解骨性关节炎疼痛。引用本文：骨关节资源2022；11(7)：439-452。
Osteoarthritis (OA) is a highly prevalent degenerative joint disorder characterized by joint pain and physical disability. Aberrant subchondral bone induces pathological changes and is a major source of pain in OA. In the subchondral bone, which is highly innervated, nerves have dual roles in pain sensation and bone homeostasis regulation. The interaction between peripheral nerves and target cells in the subchondral bone, and the interplay between the sensory and sympathetic nervous systems, allow peripheral nerves to regulate subchondral bone homeostasis. Alterations in peripheral innervation and local transmitters are closely related to changes in nociception and subchondral bone homeostasis, and affect the progression of OA. Recent literature has substantially expanded our understanding of the physiological and pathological distribution and function of specific subtypes of neurones in bone. This review summarizes the types and distribution of nerves detected in the tibial subchondral bone, their cellular and molecular interactions with bone cells that regulate subchondral bone homeostasis, and their role in OA pain. A comprehensive understanding and further investigation of the functions of peripheral innervation in the subchondral bone will help to develop novel therapeutic approaches to effectively prevent OA, and alleviate OA pain. Cite this article: Bone Joint Res 2022;11(7):439–452.