Cortical Activations in Humans Grasp-Related Areas Depend on Hand Used and Handedness
Cortical Activations in Humans Grasp-Related Areas Depend on Hand Used and Handedness
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DOI：
10.1371/journal.pone.0003388
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发表时间：
2008-10-10
期刊：
影响因子：
3.7
通讯作者：
Castiello, Umberto
中科院分区：
文献类型：
--
作者：
Begliomini, Chiara;Nelini, Cristian;Castiello, Umberto
背景：在非人灵长类动物中，与抓取相关的感觉运动转换是在一个涉及顶叶前沟（AIP区）和运动前皮层的腹侧和背侧（分别为vPMC和dPMC）的回路中完成的。虽然这种回路的人类同源物已经被确定，但该回路内的活动是否因手性而异还有待研究。方法/主要发现：我们使用功能性磁共振成像（fMRI）来明确测试惯用手如何调节人类抓取相关大脑区域的活动。在扫描过程中，右撇子和左撇子受试者被要求用右手或左手准确地握住一个物体。运动学研究采用与功能磁共振成像实验的行为研究类似的程序进行。析因设计结果显示右侧dPMC、右侧小脑和双侧AIP有显著活性。这些区域的活动模式反映了行为研究的结果。结论/意义：数据讨论了右dPMC在监测手形中的手性独立作用，精确握握运动的双侧AIP活动的需求取决于手性，以及小脑在AIP连接方面的参与。这些结果提供了第一个令人信服的证据，具体的抓相关的神经活动取决于惯用手。
Background: In non-human primates grasp-related sensorimotor transformations are accomplished in a circuit involving the anterior intraparietal sulcus (area AIP) and both the ventral and the dorsal sectors of the premotor cortex (vPMC and dPMC, respectively). Although a human homologue of such a circuit has been identified whether activity within this circuit varies depending on handedness has yet to be investigated.Methodology/Principal Findings: We used functional magnetic resonance imaging (fMRI) to explicitly test how handedness modulates activity within human grasping-related brain areas. Right-and left-handers subjects were requested to reach towards and grasp an object with either the right or the left hand using a precision grip while scanned. A kinematic study was conducted with similar procedures as a behavioral counterpart for the fMRI experiment. Results from a factorial design revealed significant activity within the right dPMC, the right cerebellum and AIP bilaterally. The pattern of activity within these areas mirrored the results found for the behavioral study.Conclusion/Significance: Data are discussed in terms of an handedness-independent role for the right dPMC in monitoring hand shaping, the need for bilateral AIP activity for the performance of precision grip movements which varies depending on handedness and the involvement of the cerebellum in terms of its connections with AIP. These results provide the first compelling evidence of specific grasping related neural activity depending on handedness.