Current understanding of the molecular and cellular pathology of diabetic retinopathy.
Current understanding of the molecular and cellular pathology of diabetic retinopathy.
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DOI：
10.1038/s41574-020-00451-4
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发表时间：
2021-04
影响因子：
40.5
通讯作者：
Stitt, Alan W.
中科院分区：
文献类型：
--
作者：
Antonetti, David A.;Silva, Paolo S.;Stitt, Alan W.
虽然糖尿病对多个器官系统有深远的影响，但糖尿病视网膜病变导致的视力丧失可能是患者一生中最大的影响之一。视网膜是一种高度代谢活跃的组织，需要跨越光感受器和神经元的细胞之间的复杂相互作用，在神经胶质和血管组织的支持下将电化学信号传递到大脑。神经元的功能依赖于视网膜细胞之间复杂的相互依存关系，其中包括血-视网膜屏障(BRB)的形成。这种动态系统受到糖尿病的负面影响，它改变了正常的细胞-细胞相互作用，导致严重的血管异常，血液屏障的丧失和神经元功能的受损。了解正常的细胞信号相互作用以及它们是如何被糖尿病改变的已经导致了新的治疗方法，改善了许多患者的视觉结果。这篇综述中强调的最新研究，使人们对糖尿病期间的视网膜病理生理学有了新的理解，并发现了治疗这种令人衰弱的疾病的新治疗途径的潜力。
While diabetes has profound effects on multiple organ systems, the loss of vision caused by diabetic retinopathy may be of one of the most impactful in a patient’s life. The retina is a highly metabolically active tissue that requires a complex interaction of cells spanning light sensing photoreceptors to neurons transferring the electrochemical signal to the brain with support by glia and vascular tissue. Neuronal function depends on a complex inter-dependency of retinal cells that includes the formation of a blood-retinal barrier (BRB). This dynamic system is negatively impacted by diabetes, which alters normal cell-cell interactions and leads to profound vascular abnormalities, loss of the blood-barriers and impaired neuronal function. Understanding the normal cell signaling interactions and how they are altered by diabetes has already led to novel therapies that have improved visual outcomes for many patients. Recent research highlighted in this review, has led to new understanding of retinal pathophysiology during diabetes and uncovered potential for new therapeutic avenues to treat this debilitating disease.
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DOI：
10.1002/stem.2810
发表时间：
2018-06
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Chambers SEJ;O'Neill CL;Guduric-Fuchs J;McLoughlin KJ;Liew A;Egan AM;O'Brien T;Stitt AW;Medina RJ
通讯作者：
Medina RJ
影响因子：
5.6
作者：
Bogdanov P;Simó-Servat O;Sampedro J;Solà-Adell C;Garcia-Ramírez M;Ramos H;Guerrero M;Suñé-Negre JM;Ticó JR;Montoro B;Durán V;Arias L;Hernández C;Simó R
通讯作者：
Simó R
影响因子：
15.9
作者：
Barber, AJ;Lieth, E;Gardner, TW
通讯作者：
Gardner, TW
影响因子：
13.7
作者：
Do, Diana V.;Quan Dong Nguyen;Heier, Jeff S.
通讯作者：
Heier, Jeff S.
影响因子：
8
作者：
Cho, Dong Im;Kong, Hye-jin;Ahn, Youngkeun
通讯作者：
Ahn, Youngkeun