Studying Viral Populations with Tools from Quantum Spin Chains
Studying Viral Populations with Tools from Quantum Spin Chains
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DOI：
10.1007/s10955-021-02716-2
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发表时间：
2020-03
影响因子：
1.6
通讯作者：
S. Shivam;C. Baldwin;J. Barton;M. Kardar;S. Sondhi
中科院分区：
文献类型：
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作者：
S. Shivam;C. Baldwin;J. Barton;M. Kardar;S. Sondhi
我们研究了准物种的特征模型（物质自组织和生物大分子进化中的特征。Naturwissenschaften 58(10):465, 1971），其特征是以特定的适应性复制并在单个位点独立突变的序列。总体向量随时间的演化与虚时间内量子自旋的演化密切相关。我们采用相互作用的量子系统的多种视角和工具来检查现实病毒种群的增长和崩溃，特别是考虑某些艾滋病毒蛋白的过度突变。使用的所有方法，包括最简单的微扰理论，都给出了一致的结果。
We study Eigen’s model of quasi-species (Eigen in Selforganization of matter and the evolution of biological macromolecules. Naturwissenschaften 58(10):465, 1971), characterized by sequences that replicate with a specified fitness and mutate independently at single sites. The evolution of the population vector in time is then closely related to that of quantum spins in imaginary time. We employ multiple perspectives and tools from interacting quantum systems to examine growth and collapse of realistic viral populations, specifically considering excessive mutations in certain HIV proteins. All approaches used, including the simplest perturbation theory, give consistent results.