Human Neurologic Function and the Aging Process †
Human Neurologic Function and the Aging Process †
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人类神经功能和衰老过程 †
DOI：
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发表时间：
1980
影响因子：
6.3
通讯作者：
J. Potvin
中科院分区：
文献类型：
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作者：
A. Potvin;K. Syndulko;W. Tourtellotte;J. Lemmon;J. Potvin
对61名年龄在20-80岁之间的正常男性进行了两次神经功能测试，共128项。这些测试测量了认知、视力、力量、稳定性、反应、速度、协调性、疲劳度、步态、站位、感觉和日常生活任务。确定每个测试测量的可靠性，并且不进一步分析任何被发现不可靠的测量(r≤0.41)。几乎所有的神经功能都发现与年龄相关的显著线性下降。年龄跨度的下降幅度从不到10%到不同功能的90%以上不等。上肢下降幅度最大(50%)的是手力稳定性、手臂运动速度和振动感；下肢下降最大的是闭眼单腿平衡和振动感。在14项测试中，有13项发现了显著的显性身体副作用，随着年龄的增长，优势身体一侧的功能损失更大。在7-10天后的重新测试中，受试者仅在17项测试中提高了5%以上，其中9项涉及日常生活能力。在不同年龄段之间，没有发现显著的学习效果差异。这些结果表明，开发基于年龄的神经功能数据库的重要性，以便可以根据年龄和性别匹配的正常功能来评估治疗效果。
Sixty‐one normal men whose ages ranged from 20 to 80 years were evaluated on two occasions by means of a comprehensive series of 128 instrumented tests of neurologic function. The tests measured cognition, vision, strength, steadiness, reactions, speed, coordination, fatigue, gait, station, sensations, and tasks of daily living. The reliability of each test measure was determined, and any measure found unreliable (r ≤ 0.41) was not further analyzed. Significant age‐related linear decreases were found for almost all neurologic functions. The declines over the age span varied from less than 10 percent to more than 90 percent for different functions. For the upper extremities, the largest declines (> 50 percent) were in hand‐force steadiness, speed of hand‐arm movements, and vibration sense; for the lower extremities, the largest declines were in one‐legged balance with eyes closed and in vibration sense. For 13 of 14 tests in which significant dominant body‐side effects were found, larger losses in function with aging were observed on the dominant body side. Upon re‐testing 7–10 days later, the subjects improved their scores by more than 5 percent on only 17 tests, 9 of which concerned the activities of daily living. No significant differential learning effects were found across age groups. The results point to the importance of developing a data bank on age‐based neurologic function so that therapeutic effects can be evaluated in terms of age‐ and sex‐matched normal functioning.