Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments.
Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments.
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在癌症诊断和治疗恢复过程中，个体的压力轨迹随免疫力变化。
DOI：
10.1016/j.bbi.2006.06.007
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Carson,WilliamE
中科院分区：
文献类型：
--
作者：
Thornton,LisaM;Andersen,BarbaraL;Crespin,TimothyR;Carson,WilliamE
研究将压力事件与免疫调节改变联系起来，但主观压力的作用尚不确定。使用纵向设计，我们提供了一个统计上强有力的测试主观压力（感知压力，情绪困扰）和免疫（T细胞发育，自然杀伤细胞细胞毒性，[NKCC]）之间的关系，因为个体适应严重的压力源，癌症诊断及其治疗。区域性乳腺癌患者（N=113）在诊断/手术时进行评估，并在4、8、12和18个月后重新评估。潜在生长曲线分析检验了两个假设：(1)主观压力的初始水平与免疫的初始水平呈负相关，(2)主观压力的变化率与免疫的变化率呈负相关。正如假设1所预测的那样，初始主观压力高的参与者表现出较差的初始胚发生。正如假设2所预测的那样，表现出早期、快速主观压力下降的参与者也表现出快速的NKCC改善。后续分析显示，感知压力与免疫功能密切相关，而情绪困扰与免疫功能无关。这是首次研究从主要压力源恢复过程中压力和免疫的轨迹。结果表明NK细胞和T细胞对应激反应的不同方面敏感。T细胞的形成与初始（峰值）主观应激相关，而NKCC与主观应激的改变（改善）相关。这些数据强调了主观压力，特别是压力评估，在对主要压力源的免疫反应中的重要性。
Research connects stressful events with altered immune regulation, but the role of subjective stress is uncertain. Using a longitudinal design, we provide a statistically powerful test of the relationship between subjective stress (perceived stress, emotional distress) and immunity (T cell blastogenesis, natural killer cell cytotoxicity, [NKCC]) as individuals adjust to a severe stressor, a cancer diagnosis and its treatments. Women with regional breast cancer (N=113) were assessed at diagnosis/surgery and reassessed 4, 8, 12, and 18 months later. Latent growth curve analysis tested two hypotheses: (1) initial levels of subjective stress will correlate inversely with initial levels of immunity, and (2) rate of change in subjective stress will correlate inversely with rate of change in immunity. As predicted by Hypothesis 1, participants with high initial subjective stress showed poor initial blastogenesis. As predicted by Hypothesis 2, participants exhibiting an early, rapid decline in subjective stress also showed rapid improvement in NKCC. Follow-up analyses revealed perceived stress to be strongly related to immune function, while emotional distress was not. This is the first study to investigate trajectories in stress and immunity during recovery from a major stressor. Results imply that NK and T cells are sensitive to different aspects of the stress response. While T cell blastogenesis correlated with initial (peak) subjective stress, NKCC correlated with change (improvement) in subjective stress. These data highlight the importance of subjective stress, particularly stress appraisals, in the immune response to a major stressor.