Synthesis and photophysical properties of water-soluble sulfonato-Salen-type Schiff bases and their applications of fluorescence sensors for Cu2+ in water and living cells.
Synthesis and photophysical properties of water-soluble sulfonato-Salen-type Schiff bases and their applications of fluorescence sensors for Cu2+ in water and living cells.
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DOI：
10.1016/j.aca.2012.05.022
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发表时间：
2012-07
影响因子：
6.2
通讯作者：
Li Zhou;Peiying Cai;Yan Feng;Jinghui Cheng;Haifeng Xiang;Jin Liu;Di Wu;Xiangge Zhou
中科院分区：
文献类型：
--
作者：
Li Zhou;Peiying Cai;Yan Feng;Jinghui Cheng;Haifeng Xiang;Jin Liu;Di Wu;Xiangge Zhou
设计并制备了一系列由1,2-乙二胺（Et-1-Et-4）、1,2-环己二胺（Cy-1和Cy-2）、1,2-苯二胺（Ph-1-Ph-3和PhMe-1-PhMe-4）和二氰-1,2-乙二胺（CN-1）等不同二胺衍生的水溶性磺化- salen型配体。配体的磺酸基保证了其在水中良好的稳定性和溶解度，而不影响其激发态性质。这些配体表现出强烈的紫外/可见光吸收和蓝色、绿色或橙色荧光。时间依赖的密度泛函理论计算揭示了配体性质，特别是磺酸基，对前沿分子轨道的影响。由于其荧光可被Cu2+选择性猝灭，因此sulfonato- salen型配体可作为高选择性和灵敏的关闭荧光传感器，用于水中Cu2+的检测和活细胞的荧光成像。
A series of water-soluble sulfonato-Salen-type ligands derived from different diamines including 1,2-ethylenediamine (Et-1–Et-4), 1,2-cyclohexanediamine (Cy-1 and Cy-2), 1,2-phenylenediamine (Ph-1–Ph-3 and PhMe-1–PhMe-4), and dicyano-1,2-ethenediamine (CN-1) has been designed and prepared. Sulfonate groups of ligands ensure good stability and solubility in water without affecting their excited state properties. These ligands exhibit strong UV/Vis-absorption and blue, green, or orange fluorescence. Time-dependent-density functional theory calculations have been undertaken to reveal the influence of ligand nature, especially sulfonate groups, on the frontier molecular orbitals. Since their fluorescence is selectively quenched by Cu2+, the sulfonato-Salen-type ligands can be used as highly selective and sensitive turn-off fluorescence sensors for the detection of Cu2+in water and fluorescence imaging in living cells.