Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit
Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit
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DOI：
10.7554/elife.18566
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发表时间：
2016-12-23
期刊：
影响因子：
7.7
通讯作者：
Soltesz, Ivan
中科院分区：
文献类型：
--
作者：
Bezaire, Marianne J.;Raikov, Ivan;Soltesz, Ivan
海马theta节律在信息加工中起着重要作用，但其产生机制尚不清楚。我们开发了一个数据驱动的、基于超级计算机的、全比例(1：1)的啮齿动物CA1区模型，并研究了其在theta振荡过程中的中间神经元。在没有节律输入的情况下，孤立的CA1回路自发地产生了具有锁相伽马振荡和不同神经元间类型的相位优先放电的Theta节律。扰动实验发现，表达小白蛋白的中间神经元和神经胶质样细胞，以及神经元间多样性本身，是theta产生的重要因素。这些模拟揭示了在theta振荡过程中CA1电路的时空组织。
The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct interneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation. These simulations reveal new insights into the spatiotemporal organization of the CA1 circuit during theta oscillations.