Study on prognostic factor in trabeculectomy with mitomycin C having history of previous glaucoma surgery
Study on prognostic factor in trabeculectomy with mitomycin C having history of previous glaucoma surgery
复制标题
有青光眼手术史的丝裂霉素C小梁切除术的预后因素研究
DOI：
10.1007/s10384-013-0257-5
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发表时间：
2013
影响因子：
2.4
通讯作者：
Tanihara H
中科院分区：
文献类型：
--
作者：
Awai-Kasaoka N;Inoue T;Inatani M;Takihara Y;Ogata-Iwao M;Tanihara H
PurposeTo evaluate the prognostic factors for surgical outcomes of subsequent trabeculectomy with mitomycin C（MMC）after prior incision glaucoma surgery.MethodsWe reviewed the medical records of a total cohort of 781 trabeculectomies with MMC，and selected 125 patients（125 eyes）.主要终点包括持续性眼内压（IOP）≥21或<5 mmHg，需要额外的青光眼手术和视力恶化至无光感。采用考克斯比例风险模型进行单因素和多因素分析。1年、2年和3年的成功概率分别为80.6%、72.2%和70.6%。多变量分析显示，青光眼手术和小梁切除术之间的时间间隔越短[相对危险度（RR），0.8867/年;P= 0.0090]，（RR，2.2645; P= 0.0029）结论青光眼手术与小梁切除术之间的间隔时间短，术后并发症少，术后并发症少并且先前小梁切除术的次数与随后小梁切除术联合MMC的手术失败相关。
PurposeTo evaluate the prognostic factors for surgical outcomes of subsequent trabeculectomy with mitomycin C (MMC) after prior incisional glaucoma surgery.MethodsWe reviewed medical records of a total cohort of 781 trabeculectomies with MMC, and selected 125 patients (125 eyes). The primary endpoints included persistent intraocular pressure (IOP) of ≥21 or <5 mmHg, the need for additional glaucoma surgery and deterioration of visual acuity to no light perception. Univariate and Multivariate analyses were performed by using the Cox proportional hazards model.ResultsThe mean follow-up period was 26.8 months. The probabilities of success at 1, 2, and 3 years were 80.6, 72.2, and 70.6 %, respectively. Multivariate analysis showed that a shorter time interval between prior glaucoma surgery and subsequent trabeculectomy [relative risk (RR), 0.8867/year;P= 0.0090] and the number of prior trabeculectomies (RR, 2.2645;P= 0.0029) were significant prognostic factors for subsequent failure of trabeculectomy with MMC.ConclusionA short time period between prior glaucoma surgery and subsequent trabeculectomy and the number of prior trabeculectomies are associated with surgical failure of subsequent trabeculectomy with MMC.