VAGINAL BLEEDING AND ADVERSE REPRODUCTIVE OUTCOMES - A METAANALYSIS
VAGINAL BLEEDING AND ADVERSE REPRODUCTIVE OUTCOMES - A METAANALYSIS
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DOI：
10.1111/j.1365-3016.1994.tb00436.x
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发表时间：
1994-01-01
影响因子：
2.8
通讯作者：
SAVITZ, DA
中科院分区：
文献类型：
--
作者：
ANANTH, CV;SAVITZ, DA
本文的目的是验证和量化阴道出血和妊娠结局之间的关系。进行荟萃分析，以量化不良生殖结果的风险，结合所有以前的研究阴道出血的证据。考虑的生殖终点是低出生体重、早产、死产、围产期死亡和先天畸形。荟萃分析证实了阴道出血与不良妊娠结局的相关性，但发现了报告的阴道出血风险以及出血与不良生殖结局之间相关性的差异，这些差异在研究中观察到。这些差异可能是由于阴道出血的时间和严重程度的定义不一致。这种不一致的影响进行了讨论，建议在未来的研究中需要更标准化的定义阴道出血和生殖终点。
The objective of this paper is to characterise and quantify the association between vaginal bleeding and pregnancy outcome. A meta-analysis was performed in order to quantify the risk of adverse reproductive outcome by combining evidence from all previous studies of vaginal bleeding. The reproductive endpoints considered were low birthweight, preterm birth, stillbirth, perinatal death and congenital malformation. The meta-analysis confirms an association of vaginal bleeding with adverse pregnancy outcomes, but identified discrepancies in the reported risks of vaginal bleeding and magnitudes of association between bleeding and adverse reproductive outcomes, observed across studies. These discrepancies may be attributed to inconsistent definitions of the timing and severity of vaginal bleeding. The implications of such inconsistencies are discussed, suggesting a need for more standardised definitions of vaginal bleeding and reproductive endpoints in future studies.