Quantification of angiogenesis in solid human tumours: An international consensus on the methodology and criteria of evaluation
Quantification of angiogenesis in solid human tumours: An international consensus on the methodology and criteria of evaluation
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DOI：
10.1016/s0959-8049(96)00379-6
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发表时间：
1996-12-01
影响因子：
8.4
通讯作者：
Dirix, LY
中科院分区：
文献类型：
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作者：
Vermeulen, PB;Gasparini, G;Dirix, LY
肿瘤血管生成被认为是由血管生成刺激水平的增加和伴随的血管生成抑制物水平的降低启动的[L]。正负向血管生成调节因子的局部净效应基于(I)肿瘤细胞、间质细胞、炎症细胞和细胞外基质成分的活性(旁分泌相互作用)，(Ii)内皮细胞的活性(自分泌相互作用)和(Iii)循环因子的流入(内分泌相互作用)。肿瘤的生长、侵袭和转移都需要血管生成[2]。这些病理生理过程的强度对个体癌症患者的预后有很大影响。这反映在临床和病理分期标准上。各种实验表明，血管生成的程度与恶性肿瘤局部扩散和远处扩散的能力密切相关。血管生成是宿主组织特征的反映。例如，肿瘤在老年小鼠身上生长较慢的事实很好地说明了这一点[3]。癌症研究的兴趣领域正在向肿瘤相关的间质组织转移。最近发现了肿瘤细胞表型和血管内皮细胞表型之间重要的直接和间接关系。
TUMOUR ANGIOGENESIS is thought to be initiated by an increase in the level of angiogenic stimuli and a concomitant decrease in the level of angiogenesis inhibitors[l]. The locoregional net effect of positive and negative regulators of angiogenesis is based (i) on the activity of tumour cells, stromal cells, inflammatory cells and extracellular matrix components(paracrine interactions),(ii) on the activity of endothelial cells (autocrine interaction) and (iii) on the influx of circulating factors(endocrine interactions). Tumour growth, invasion and metastasis all require angiogenesis[2]. Prognosis of individual cancer patients is profoundly influenced by the intensity of these pathophysiological processes. This is reflected in the clinical and pathological staging criteria. Various experiments suggest that the degree of angiogenesis is closely related to the capacity of a malignant tumour to expand locally and to give rise to distant spread.Angiogenesis is a reflection of the characteristics of the host tissue. This is, for instance, elegantly illustrated by the fact that tumours grow more slowly in elderly mice [3]. The field of interest of cancer research is shifting towards the tumour-associated stromal tissue. Important direct and indirect relationships between tumour cell phenotypes and endothelial cell phenotypes have recently been revealed.