Therapeutic targeting of autophagy in myocardial infarction and heart failure
Therapeutic targeting of autophagy in myocardial infarction and heart failure
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DOI：
10.1080/14779072.2016.1202760
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发表时间：
2016-06
影响因子：
2
通讯作者：
Jaime A Riquelme;Myra N. Chávez;David Mondaca-Ruff;M. Bustamante;J. Vicencio;A. Quest;S. Lavandero
中科院分区：
文献类型：
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作者：
Jaime A Riquelme;Myra N. Chávez;David Mondaca-Ruff;M. Bustamante;J. Vicencio;A. Quest;S. Lavandero
摘要引言：心肌梗死（MI）是死亡的主要原因。当MI不致命时，心力衰竭（HF）是一个主要的后果，患病率高，预后差。靶向自噬代表了治疗这两种病理的潜在治疗方法。所涵盖的领域：进行PubMed检索，以讨论自噬在MI和HF中作用的最新技术水平。我们从药理学和遗传学的角度综述了现有的和潜在的调节自噬的方法。我们还讨论了自噬在心肌再生中的靶向作用。专家评论：靶向自噬具有治疗MI和HF的潜力。自噬是一个发生在身体几乎所有细胞中的过程，因此，为了在临床试验中评估这种治疗方法，需要在心肌中特异性靶向该过程的策略，以避免在其他器官中产生不必要的影响。
ABSTRACT Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a potentially therapeutic approach for the treatment of both pathologies. Areas covered: PubMed searches were performed to discuss the current state of the art regarding the role of autophagy in MI and HF. We review available and potential approaches to modulate autophagy from a pharmacological and genetic perspective. We also discuss the targeting of autophagy in myocardial regeneration. Expert commentary: The targeting of autophagy has potential for the treatment of MI and HF. Autophagy is a process that takes place in virtually all cells of the body and thus, in order to evaluate this therapeutic approach in clinical trials, strategies that specifically target this process in the myocardium is required to avoid unwanted effects in other organs.