Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract:: the prospective EPIC-study
Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract:: the prospective EPIC-study
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DOI：
10.1007/s10552-006-0036-4
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发表时间：
2006-09-01
影响因子：
2.3
通讯作者：
Riboli, Elio
中科院分区：
文献类型：
--
作者：
Boeing, Heiner;Dietrich, Thomas;Riboli, Elio
流行病学研究表明，水果和蔬菜的高摄入量与上消化道癌症风险的降低有关。我们研究了在七个欧洲国家招募的345,904名未来欧洲癌症与营养调查(EPIC)受试者的数据，这些受试者在1992-1998年间完成了饮食调查问卷。在2182,560人年的观察期间，352例经组织学证实的口腔、咽、喉和食道的鳞状细胞癌(SCC)病例(男性255例，女性97例)被确认。对水果和蔬菜摄入量的变量进行线性和限制三次样条Cox回归，并对潜在的混杂因素进行了调整。我们观察到水果和蔬菜的总摄入量与总摄入量呈显著负相关(估计相对危险度(RR)=0.91；95%可信区间(95%CI)0.83-1.00/80g/d)，而在单独的分析中，与总水果和总蔬菜摄入量几乎呈显著负相关(RR：0.97(95%CI：0.92-1.02)和RR=0.89(95%CI：0.78-1.02)/40 g/d)。总体而言，除了男性摄入块根类蔬菜外，蔬菜亚类与风险无关。限制三次样条法回归并未改善线性模型的拟合度，但水果总摄入量(1t；120g/d)对总水果和总水果的风险有显著降低。饮食建议应考虑增加水果和蔬菜摄入量对降低上消化道癌症风险的潜在益处，特别是在低摄入量的情况下。
Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (< 120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.