Presurgical assessment of cognitive function in pediatric brain tumor patients: feasibility and initial findings.
Presurgical assessment of cognitive function in pediatric brain tumor patients: feasibility and initial findings.
复制标题
儿科脑肿瘤患者认知功能的术前评估：可行性和初步发现。
DOI：
10.1093/nop/npv066
复制
发表时间：
2016
影响因子：
2.7
通讯作者：
Compas,BruceE
中科院分区：
文献类型：
--
作者：
Thigpen,JenniferC;Pearson,Matthew;Robinson,KristenE;Andreotti,Charissa;Dunbar,JenniferP;Watson,KellyH;Dejardins,Leandra;Holmes,Lindsay;Byram,Rebecca;Fraley,Claire;Compas,BruceE
研究背景为儿童脑肿瘤患者建立术前神经认知功能的基线是确定其功能水平的优先事项。然而，很少有研究已经获得了足够的样本presurgery assessment.MethodsThis研究探讨完成测试，以评估手术前的神经认知功能在59个确定的小儿脑肿瘤patients.Results85%的患者（n= 50）被称为神经外科手术前的团队和83%的患者（n= 49）参加了这项研究的可行性。对54%（n= 32）的患者进行了一系列完整的神经认知功能测试，包括基于表现和父母报告的神经认知功能测试。父母报告或基于表现的测量的完成率分别为68%（n= 40）和69%（n= 41）。虽然基于表现的评估在平均范围内（M = 95.4，SD = 14.7，95%CI，90.7-100.0），但32%的参与者的评分低于平均值一个或多个标准差，或预期率的两倍。父母报告显示比一般人群更高的关注水平（M = 55.4，SD = 11.3，95% CI，51.8-59.0），发现35%的患者比平均值高出一个或多个标准差，或超过预期率的两倍。结论结果表明，在诊断时对部分儿科脑肿瘤患者进行手术评估，这些结果与先前的研究相比是有利的。然而，近一半的患者没有接受完整的测试组合。识别入学和参与研究的障碍进行了讨论，以及对未来研究的建议。
BackgroundEstablishing a presurgical baseline of neurocognitive functioning for pediatric brain tumor patients is a high priority to identify level of functioning prior to medical interventions. However, few studies have obtained adequate samples of presurgery assessments.MethodsThis study examines the feasibility of completing tests to assess pre-surgical neurocognitive functioning in 59 identified pediatric brain tumor patients.ResultsEighty-five percent of patients (n= 50) were referred by the neurosurgery team before surgery and 83% of patients (n= 49) enrolled in the study. A full battery, includingbothperformance-based and parent-report measures of neurocognitive function, was completed for 54% (n= 32) of patients. Rates of completion foreitherparent-report or performance-based measures were 68% (n= 40) and 69% (n= 41), respectively. While the performance-based assessment fell within the average range (M = 95.4, SD = 14.7, 95% CI, 90.7–100.0), 32% of participants had scores one or more standard deviations below the mean, or twice the expected rate. Parent-reports indicated higher level of concern than the general population (M = 55.4, SD = 11.3, 95% CI, 51.8–59.0) and found that 35% fell one or more standard deviations above the mean, or more than twice the expected rate.ConclusionsResults suggest it is feasible to conduct pre-surgical assessments with a portion of pediatric brain tumor patients upon diagnosis and these results compare favorably with prior research. However, nearly half of identified patients did not receive a full test battery. Identifying barriers to enrollment and participation in research are discussed as well as recommendations for future research.