Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses
Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses
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DOI：
10.1002/adma.201504527
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发表时间：
2016-03-23
影响因子：
29.4
通讯作者：
Omenetto, Fiorenzo G.
中科院分区：
文献类型：
--
作者：
Applegate, Matthew B.;Partlow, Benjamin P.;Omenetto, Fiorenzo G.
报道了一种以核黄素（维生素B2）为光引发剂的丝素蛋白光交联新方法，并对交联机理进行了探讨。将核黄素掺杂的液体丝溶液暴露于光导致形成透明的弹性水凝胶。研究了这种新材料的几种应用，包括角膜重塑以恢复视力和光刻。[图形]。
A novel method to photocrosslink silk fibroin protein is reported, using riboflavin (vitamin B2) as a photoinitiator and the mechanism of crosslinking is determined. Exposure of riboflavin-doped liquid silk solution to light results in the formation of a transparent, elastic hydrogel. Several applications for this new material are investigated including corneal reshaping to restore visual acuity and photolithography.[GRAPHICS].