Giessen Wholesome Nutrition Study: relation between a health-conscious diet and blood lipids
Giessen Wholesome Nutrition Study: relation between a health-conscious diet and blood lipids
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DOI：
10.1038/sj.ejcn.1601243
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发表时间：
2001-10-01
影响因子：
4.7
通讯作者：
Leitzmann, C
中科院分区：
文献类型：
--
作者：
Hoffmann, I;Groeneveld, MJ;Leitzmann, C
目的：研究健康饮食(健康营养)与血脂(总胆固醇、低密度脂蛋白、高密度脂蛋白胆固醇、低密度脂蛋白/高密度脂蛋白比值、甘油三酯)之间的关系。设计：两个饮食组的横断面研究。地点：前西德人。研究对象：243名健康女性(年龄25-65岁)，坚持健康营养至少5年(细分为111名乳蛋素食者和132名低肉食者)和175名吃普通德国混合饮食的对照组。他们都是通过广告活动招募的，并根据他们的食物摄入量进行选择。结果：考虑潜在的混杂因素，健康营养亚组的高密度脂蛋白-胆固醇水平高于对照组。在总胆固醇和低密度脂蛋白-胆固醇方面没有观察到差异。对于低密度脂蛋白/高密度脂蛋白比值和甘油三酯，饮食的影响依赖于相互作用项。随着危险因素(年龄或体重指数(BMI))的增加，健康营养亚组显示出更有利的血脂。结论：长期食用预防性饮食的女性比食用普通混合饮食的女性表现出更有利的血脂谱。对于存在某些危险因素的高密度脂蛋白-胆固醇来说，这一点尤其明显，尤其是在实行鸡蛋-乳素版本的时候。
Objective: To study in humans the relationship between a diet consistent with most of the current recommendations for the prevention of nutrition-related diseases (Wholesome Nutrition) and the blood lipid profile (total cholesterol, LDL-, HDL-cholesterol, LDL/HDL-ratio, triglycerides).Design: Cross-sectional study with two diet groups.Setting: Former West Germany.Subjects: Healthy women (n = 243, aged 25 - 65 y) adhering to Wholesome Nutrition for at least 5 y (subdivided into 111 ovo-lacto vegetarians and 132 low-meat eaters) and an according control group of 175 women eating an average German mixed diet. They were all recruited through an advertisement campaign and selected on the basis of their food consumption.Results: Considering potential confounders, the Wholesome Nutrition subgroups had higher HDL-cholesterol levels than the control group. No differences were observed for total cholesterol and LDL-cholesterol. For LDL/HDL-ratio and triglycerides the effect of diet was dependent on interaction terms. With increasing risk factors (age or body mass index (BMI)) the Wholesome Nutrition subgroups showed more favourable blood lipids.Conclusions: Women eating a preventive diet on a long-term basis exhibit more favourable blood lipid profiles than women consuming an average mixed diet. This is particularly obvious for HDL-cholesterol in the presence of certain risk factors and when an ovo-lacto vegetarian version is practised.