Rapid synthesis of a glycosylphosphatidylinositol-based malaria vaccine using automated solid-phase oligosaccharide synthesis
Rapid synthesis of a glycosylphosphatidylinositol-based malaria vaccine using automated solid-phase oligosaccharide synthesis
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DOI：
10.1021/ja027538k
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发表时间：
2002-11-13
影响因子：
15
通讯作者：
Seeberger, PH
中科院分区：
文献类型：
--
作者：
Hewitt, MC;Snyder, DA;Seeberger, PH
描述了一种自动合成的六糖疟疾毒素1，目前正在开发中，作为一种疟疾候选疫苗。采用自动化固相法和液相片段耦合相结合的方法，目标糖基磷脂酰银耳醇在几天内组装完成，而类似的液相合成则需要数周时间。
Described is an automated synthesis of hexasaccharicle malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphaticlylincisitol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.