Intrinsic rhythmic propulsion of lymph in the unanaesthetlzed sheep
Intrinsic rhythmic propulsion of lymph in the unanaesthetlzed sheep
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DOI：
10.1113/jphysiol.1965.sp007706
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发表时间：
1965-01-01
期刊：
影响因子：
--
通讯作者：
WOOLLEY, G.
中科院分区：
文献类型：
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作者：
HALL, J. G.;MORRIS, B.;WOOLLEY, G.
在清醒羊的腘窝淋巴结、腰椎淋巴干、卵巢淋巴管、乳腺淋巴管、肠淋巴干、肝淋巴管、胸管、颈深淋巴管和尾侧颈浅淋巴结的传出淋巴管的传入和传出淋巴管中建立了淋巴瘘。淋巴从这些淋巴瘘管中流出是间歇性的，有一种特有的节奏，与肌肉运动无关，除了胸导管与呼吸无关。记录不同淋巴管的脉压：脉压范围为1 ~ 25mmhg，脉频范围为1 ~ 30/min。随着淋巴流量的增加，压力脉冲的大小和速率也随之增加。当各种淋巴管被夹住以阻止淋巴液流动时，淋巴管的压力升高，收缩的频率增加。记录的最大压力为60毫米汞柱。可以检测到肌肉、循环和呼吸运动对淋巴管（胸导管除外）压力记录的影响，但这些影响很小。胸导管的压力记录显示了内在的有节奏的脉动，在脉动上叠加了由呼吸引起的压力波动。结论是，在未麻醉的绵羊中，有瓣淋巴管固有的节律性收缩主要负责将淋巴从周围推进到胸导管。由于这些收缩的强度和频率与淋巴形成的速率有关，这种机制的作用是控制组织液的清除，其速率与形成速率成正比。摘要作者：作者
Lymphatic fistulae were established in conscious sheep in the afferent and efferent vessels of the popliteal lymph node, the lumbar lymphatic trunk, the ovarian lymph duct, the mammary lymph duct, the intestinal lymphatic trunk, the hepatic lymph duct, the thoracic duct, the deep cervical lymph duct and the efferent lymphatic from the caudal superficial cervical lymph node. The flow of lymph from all these lymphatic fistulae was intermittent with a characteristic rhythm that was unrelated to muscle movements and except in the case of the thoracic duct unrelated to respiration. Pulsatile pressures were recorded from the various lymphatics: pulse pressures ranged from 1 to 25 mm Hg with pulse frequencies from 1 to 30/min. The magnitude of the pressure pulses and their rate increased as the rate of lymph flow increased. When the various lymphatic can-nulae were clamped to prevent lymph flow the pressures in the lymphatics rose and the frequency of contractions increased. Maximum pressures recorded were 60 mm Hg. It was possible to detect effects of muscular, circulatory and respiratory movements on the pressure records from lymphatics other than the thoracic duct but these effects were small. The pressure record from the thoracic duct showed intrinsic rhythmic pulsations on which were superimposed fluctuations in pressure which were due to respiration. The conclusion was drawn that in the unanaesthetized sheep the intrinsic rhythmic contractions of the valved lymphatic vessels are primarily responsible for the propulsion of lymph from the periphery to the thoracic duct. As the strength and frequency of these contractions are related to the rate of lymph formation, this mechanism acts to control the removal of tissue fluid at a rate proportional to its rate of formation. || ABSTRACT AUTHORS: Authors