Genetic Suppression Meets Structure Prediction: Probing a Spore Germination Receptor Complex.
Genetic Suppression Meets Structure Prediction: Probing a Spore Germination Receptor Complex.
复制标题
遗传抑制与结构预测的结合：探测孢子萌发受体复合体。
DOI：
10.1128/jb.00579-21
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发表时间：
2022
影响因子：
3.2
通讯作者：
Popham,DavidL
中科院分区：
文献类型：
--
作者：
Moir,Anne;Popham,DavidL
尽管在芽孢杆菌和梭菌的基因组中发现了数千种孢子萌发受体操纵子，但对这三种基本受体组分如何在萌发中作为信号转导机器的理解仍然有限。Amon等人的论文在本期中使用经典的遗传抑制方法来定义GerAA和GerAB蛋白质之间可能相互作用的区域：它提供了对受体复合物内潜在事件的第一次一瞥（J. D.阿蒙湖Artzi和D. Z. Rupert，J Bacteriol 204：e00470-21，2022，https：//doi.org/10.1128/JB.00470-21）。
Despite the thousands of spore germinant receptor operons identified in genomes of bacilli and clostridia, understanding how the three essential receptor components act as a signal transduction machine in germination remains limited. The paper by Amon et al. in this issue uses the classical genetic approach of suppression to define a region of likely interaction between the GerAA and GerAB proteins: it provides a first glimpse into potential events within the receptor complex (J. D. Amon, L. Artzi, and D. Z. Rudner, J Bacteriol 204:e00470-21, 2022, https://doi.org/10.1128/JB.00470-21).