The nocturnal rise of human prolactin is dependent on sleep.
The nocturnal rise of human prolactin is dependent on sleep.
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人类催乳素的夜间升高依赖于睡眠。
DOI：
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发表时间：
1973
影响因子：
5.8
通讯作者：
E. Weitzman
中科院分区：
文献类型：
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作者：
J. Sassin;A. Frantz;S. Kapen;E. Weitzman
这项研究提供了催乳素升高与睡眠有关的进一步证据，该研究推迟了4名正常患者(3名女性和1名男性)的睡眠开始，并颠倒了正常的睡眠-觉醒周期。倒置计划持续3周，最后进行了12小时的实验室研究，用放射免疫法测定血浆催乳素和生长激素水平。在第一名女性受试者中，平均催乳素水平(ng/ml)在基线和换班后分别为7和8.3；病例2(女性)为7.3和5.9；病例3(男性)为6.1和6.1；最后一例分别为4.7和4.3。病例1基线和换班后生长激素水平分别为1.5和1.5，病例2分别为1.1和2.5，病例3分别为1.8和1.1，病例4分别为7.3和5.2。催乳素的释放立即完全改变，睡眠开始时间为3、6和12小时。由此得出结论，夜间上升取决于睡眠的发生，而不是与一天中的时间有关的内在节律。
Further evidence that there is a relationship between prolactin rise and sleep is offered by this study that delayed sleep onset and inverted the normal sleep-waking cycle in 4 normal patients (3 women and 1 man). The inversion schedule lasted 3 weeks, and at its conclusion a final 12-hour laboratory study was carried out measuring the plasma levels of human prolactin and growth hormone by radioimmunoassay. In the first female subject, mean prolactin levels (ng/ml) were, for baseline and after shift, 7 and 8.3; for case 2 (female) the values were 7.3 and 5.9; for case 3 (male) the levels were 6.1 and 6.1; and for the last case, the levels were 4.7 and 4.3, respectively. Values for growth hormone were (ng/ml) 1.5 and 1.5 for Case 1 for baseline and after shift, respectively; 1.1 and 2.5 for Case 2, respectively; 1.8 and 1.1 for Case 3, respectively; and 7.3 and 5.2 for Case 4, respectively. Prolactin release shifted immediately and completely with shifts of sleep onset of 3, 6, and 12 hours. Thus, it is concluded that the nocturnal rise is dependent on the occurrence of sleep, not on the inherent rhythm related to time of day.