O-LINKED N-ACETYLGLUCOSAMINE IS UP-REGULATED IN ALZHEIMER BRAINS
O-LINKED N-ACETYLGLUCOSAMINE IS UP-REGULATED IN ALZHEIMER BRAINS
复制标题
DOI：
10.1006/bbrc.1995.2149
复制
发表时间：
1995-08-15
影响因子：
3.1
通讯作者：
SCHMITZ, B
中科院分区：
文献类型：
--
作者：
GRIFFITH, LS;SCHMITZ, B
我们提出的证据表明，新的细胞内糖修饰蛋白质O-糖基连接N-乙酰氨基葡萄糖(O-GlcNAc)-在阿尔茨海默病脑中的表达显著高于年龄匹配的对照组大脑。这种增加是与洗涤剂不溶细胞骨架相关的蛋白质特有的，而不是洗涤剂可溶部分的蛋白质，也不是由于该部分的蛋白质表达增加所致。提示细胞内O-GlcNAc表达水平的升高可能参与了阿尔茨海默病的发病机制。(C)1995年学术出版社。
We present evidence that the expression of the novel intracellular carbohydrate modification of proteins O-glycosidically linked N-acetylglucosamine (O-GlcNAc) - is significantly upregulated in Alzheimer brains over that of age matched control brains. This increase is specific for proteins associated with the detergent insoluble cytoskeleton and not for proteins of the detergent soluble fraction and is not due to an increase in protein expression in this fraction. The possible involvement of abnormal phosphorylation in the disease state and the interplay between phosphorylation and the O-GlcNAc modification suggests that the increased level of intracellular O-GlcNAc expression may be implicated in the pathogenesis of Alzheimer's disease. (C) 1995 Academic Press, Inc.