Long-term effects of rapid weight gain in children, adolescents and young adults with appropriate birth weight for gestational age: the kiel obesity prevention study
Long-term effects of rapid weight gain in children, adolescents and young adults with appropriate birth weight for gestational age: the kiel obesity prevention study
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DOI：
10.1111/j.1651-2227.2009.01573.x
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发表时间：
2010-02-01
期刊：
影响因子：
3.8
通讯作者：
Mueller, M. J.
中科院分区：
文献类型：
--
作者：
Hitze, B.;Bosy-Westphal, A.;Mueller, M. J.
目的：研究适龄出生的足月儿、青少年和青壮年体重快速增加的影响。方法：共调查了173名女孩和178名男孩，年龄为6.1-19.9岁(12.5+/-3.1岁)。体重快速增长(组1)被定义为体重从出生到两年的变化-标准差(SDS值)=0.67，不变=-0.67；组2(组2)与体重缓慢增长(组2)相比，90岁/性别特定的BMI百分位数被定义为超重。结果：22.8%的儿童体重迅速增加，15.7%的儿童超重。第1组比第2组和第3组更高、更重，超重的发生率也更高(女生/男生：26.2%/28.9%比11.6%/19.0%比2.8%/5.0%；p<；0.01/p<；0.05)。同时，观察到较高的WC、%Fm和FFm。在男孩中，快速体重增加与REE(调整了FFM)呈正相关(r=0.26；p<；0.01)，但与心脏代谢危险因素无关。结论：快速体重增加与身高、体重增加、超重发生率较高和中心脂肪分布有关。此外，体重快速增加与男孩体内较高的稀土元素有关，但与心脏代谢风险因素无关。
Aim:This study investigates the effect of rapid weight gain in term children, adolescents and young adults born appropriate for gestational age.Methods:In all, 173 girls and 178 boys aged 6.1-19.9 (12.5 +/- 3.1)years participated. Rapid weight gain (group 1) was defined as a change in weight-SDS (standard deviation score) from birth till two years > 0.67, 'no change' as >=-0.67 and < 0.67 (group 2) vs 'slow weight gain' as 90th age-/sex-specific BMI-percentile was defined as overweight. Parental BMI, socio-economic status and lifestyle were assessed as confounders.Results:A total of 22.8% gained weight rapidly, and 15.7% was overweight. Group 1 compared with group 2 and 3 subjects was taller, heavier and had a higher prevalence of overweight (girls/boys: 26.2%/28.9% vs 11.6%/19.0% vs 2.8%/5.0%; p < 0.01/p < 0.05). Concomitantly, a higher WC, %FM and FFM were observed. Rapid weight gain was positively associated with REE (adjusted for FFM) in boys (r = 0.26; p < 0.01), but not with cardio-metabolic risk factors.Conclusion:Rapid weight gain was related to increases in height, weight, a higher prevalence of overweight and central fat distribution. In addition, rapid weight gain was related to a higher REE in boys, but not to cardio-metabolic risk factors.