Tumor induction in tracheal grafts: a new experimental model for respiratory carcinogenesis studies.
Tumor induction in tracheal grafts: a new experimental model for respiratory carcinogenesis studies.
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气管移植物中的肿瘤诱导：呼吸道癌发生研究的新实验模型。
DOI：
10.1093/jnci/52.4.1317
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
A. S. Hammons
中科院分区：
文献类型：
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作者：
J. Kendrick;P. Nettesheim;A. S. Hammons
我们描述了大鼠、小鼠和仓鼠皮下气管移植的长期存活。在已建立的大鼠气管移植物中注入致癌性多环烃，可在4-7天内发生增生、不典型增生和鳞状化生。香烟烟雾冷凝物也会引起类似的上皮变化。在一项仍在进行中的研究中，在注入5mg 3-甲基胆蒽或苯并[a]芘后的26至35周内，13例气管移植物中有7例发生了浸润性鳞状细胞癌。在接受1mg n -亚硝基甲基脲的移植物中尚未出现肿瘤。我们讨论了该实验模型在形态发生和共癌发生研究中的实用性。
We described long-term survival of subcutaneous tracheal transplants in rats, mice, and hamsters. Instillation of carcinogenic polycyclic hydrocarbons into established rat tracheal grafts resulted in the development of hyperplasia, dysplasia, and squamous metaplasia within 4–7 days. Similar epithelial changes were also induced with cigarette smoke condensate. In one study, which is still in progress, invasive squamous cell carcinomas developed in 7 of 13 tracheal grafts between 26 and 35 weeks after instillation of 5 mg of either 3-methyl-cholanthrene or benzo[a]pyrene. No tumors have as yet appeared in grafts receiving 1 mg ofN-nitroso-methylurea. We discussed the usefulness of this experimental model for morphogenesis and cocarcinogenesis studies.