Auditory Oddball Deficits in Schizophrenia: An Independent Component Analysis of the fMRI Multisite Function BIRN Study
Auditory Oddball Deficits in Schizophrenia: An Independent Component Analysis of the fMRI Multisite Function BIRN Study
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DOI：
10.1093/schbul/sbn133
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发表时间：
2009-01-01
影响因子：
6.6
通讯作者：
Calhoun, V. D.
中科院分区：
文献类型：
--
作者：
Kim, Dae Il;Mathalon, D. H.;Calhoun, V. D.
大脑区域之间的连接缺陷被认为在精神分裂症的病理生理学中起着重要作用。精神分裂症的功能性磁共振成像（fMRI）分析，采用独立成分分析（伊卡），以确定多个时间内聚，空间分布的大脑活动区域，代表功能连接的网络。我们假设，功能连接的差异将被视为听觉网络组成的区域，如上级颞回，以及执行网络组成的额顶叶区。在听觉古怪范式中，发现八个网络与精神分裂症有关。其中包括一个包含上级和颞中回的双侧颞叶网络;一个由后扣带回、楔前叶和额中回组成的默认模式网络;以及多个背外侧前额叶皮层网络，这些网络构成了不同水平的组间差异。这些结果表明，精神分裂症患者在听觉加工、执行控制和基线功能活动相关的网络中表现出功能连接差异。总的来说，这些发现支持这样的想法，即与精神分裂症相关的认知缺陷是广泛的，功能连接方法可以帮助阐明这种疾病的神经相关性。
Deficits in the connectivity between brain regions have been suggested to play a major role in the pathophysiology of schizophrenia. A functional magnetic resonance imaging (fMRI) analysis of schizophrenia was implemented using independent component analysis (ICA) to identify multiple temporally cohesive, spatially distributed regions of brain activity that represent functionally connected networks. We hypothesized that functional connectivity differences would be seen in auditory networks comprised of regions such as superior temporal gyrus as well as executive networks that consisted of frontal-parietal areas. Eight networks were found to be implicated in schizophrenia during the auditory oddball paradigm. These included a bilateral temporal network containing the superior and middle temporal gyrus; a default-mode network comprised of the posterior cingulate, precuneus, and middle frontal gyrus; and multiple dorsal lateral prefrontal cortex networks that constituted various levels of between-group differences. Highly task-related sensory networks were also found. These results indicate that patients with schizophrenia show functional connectivity differences in networks related to auditory processing, executive control, and baseline functional activity. Overall, these findings support the idea that the cognitive deficits associated with schizophrenia are widespread and that a functional connectivity approach can help elucidate the neural correlates of this disorder.