Orbitofrontal correlates of aggression and impulsivity in psychiatric patients
Orbitofrontal correlates of aggression and impulsivity in psychiatric patients
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DOI：
10.1016/j.pscychresns.2005.05.016
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发表时间：
2006-10-30
影响因子：
2.3
通讯作者：
Fulwiler, Carl
中科院分区：
文献类型：
--
作者：
Antonucci, Ami Sheth;Gansler, David A.;Fulwiler, Carl
在一组不同的非精神病精神病患者中，研究了眼眶额叶皮质(OFC)体积与攻击性和冲动性之间的关系。来自两个不同精神科诊所(新英格兰医学中心和Lemuel Shattuck医院)的15名具有各种诊断的非精神病受试者被顺序转介进行磁共振成像(MRI)以用于临床目的。这一方便的样本在评估时临床稳定，接受了标准化的精神病学诊断访谈、攻击性和冲动性心理测量(Barratt冲动性、攻击史和Buss-Perry攻击性量表)，以及带有图像分析的MRI方案。OFC灰质体积、总体积以及左右灰质体积与运动冲动显著正相关。OFC的不对称性与攻击性有关，尽管总体、左侧和右侧的OFC容量测量与攻击性无关。对于没有情感障碍的受试者，OFC与Barratt冲动性量表中的运动和无计划的子量表有很强的正相关性。对于有情感障碍的受试者，OFC的不对称性与这两种攻击性心理测量学都有很强的关联。与预期一致的是，结果提示OFC参与了冲动和攻击性的神经回路。这些发现表明，OFC与攻击性和冲动有关的角色是分离的，因此OFC可能参与了对攻击行为的调节，并在冲动行为中发挥了生成性作用。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
The association between orbital frontal cortex (OFC) volume and aggression and impulsivity was investigated among a heterogeneous group of non-psychotic psychiatric clients. Fifteen non-psychotic subjects from two different psychiatric clinics (New England Medical Center and Lemuel Shattuck Hospital) with a variety of diagnoses were sequentially referred for magnetic resonance imaging (MRI) for clinical purposes. This convenience sample, clinically stable at the time of evaluation, received a standardized psychiatric diagnostic interview, aggression and impulsivity psychometrics (Barratt Impulsivity, Lifetime History of Aggression, and Buss-Perry Aggression scales), and an MRI protocol with image analysis. OFC gray matter volume, total as well as left and right, was significantly and positively associated with motor impulsivity. OFC asymmetry was associated with aggression, though total, left, and right OFC volume measurements were not. For subjects without affective disorder, there was a strong and positive association of the OFC to motor and no-planning subscales of the Barratt Impulsivity Scale. For subjects with affective disorder, there was a strong association of OFC asymmetry to both of the aggression psychometrics. Consistent with expectation, results are suggestive of OFC involvement in the neural circuitry of impulsivity and aggression. The findings suggest a dissociation of the role of the OFC in relation to aggression and impulsivity, such that the OFC may play a part in the regulation of aggressive behavior and a generative role in impulsive behavior. (c) 2006 Elsevier Ireland Ltd. All rights reserved.