2R,4R-4-Aminopyrrolidine-2,4-dicarboxylate (APDC) attenuates cortical EPSPs.
2R,4R-4-Aminopyrrolidine-2,4-dicarboxylate (APDC) attenuates cortical EPSPs.
复制标题
2R,4R-4-Aminopyrrolidine-2,4-dicarboxylate (APDC) 可减弱皮质 EPSP。
DOI：
10.1016/s0006-8993(00)02429-x
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发表时间：
2000
期刊：
影响因子：
2.9
通讯作者：
Daw,NW
中科院分区：
文献类型：
--
作者：
Flavin,HJ;Jin,XT;Daw,NW
在大鼠视皮层脑片上研究了Ⅱ型代谢型谷氨酸受体（mGluR 2，3）激动剂APDC对神经元反应的影响。在所有皮层层，APDC衰减的EPSP刺激的主要兴奋性输入。这种EPSP衰减在年轻和年老的大鼠脑片中均可见，并且在记录的细胞中存在G蛋白阻断，表明这是突触前效应。此外，这种EPSP衰减被mGluR 2，3拮抗剂EGLU阻断。APDC对NMDA反应的突触后抑制作用见于第2层和第3层，但不见于第5层和第6层。因此，II型mGluRs在视觉皮层中的主要作用是突触前谷氨酸释放的减少，其在发育过程中持续存在。这种调节在视皮层兴奋性音调的设置和视觉信息的提取/处理中可能是重要的。
We studied the effect of the Type II metabotropic glutamate receptor (mGluR 2,3) agonist APDC on the response of neurons in slices of rat visual cortex. In all cortical layers, APDC attenuated the EPSP produced by stimulation of the predominant excitatory input. This EPSP attenuation was seen in both younger and older rat slices and was present with G-protein blockade in the cell recorded, demonstrating that it was a presynaptic effect. Further, this EPSP attenuation was blocked by the mGluR 2,3 antagonist EGLU. A postsynaptic depressive effect of APDC on the NMDA response was seen in layers 2 and 3, but not in layers 5 and 6. Thus, the predominant action of Type II mGluRs in the visual cortex is a presynaptic reduction of glutamate release which persists through development. This regulation may be important in the setting of excitatory tone in visual cortex and in the extraction/processing of visual information.