Exocytotic Ca2+ channels in mammalian central neurons
Exocytotic Ca2+ channels in mammalian central neurons
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DOI：
10.1016/0166-2236(95)80030-6
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发表时间：
1995-02
影响因子：
15.9
通讯作者：
K. Dunlap;J. Luebke;T. Turner
中科院分区：
文献类型：
--
作者：
K. Dunlap;J. Luebke;T. Turner
细胞内钙离子启动多种生理事件，如基因转录、肌肉收缩、细胞分裂和胞吐作用。可以预见的是，引起和响应细胞内钙离子变化的代谢机制相应地是不同的。这篇综述集中在这一复杂网络中对神经生物学家特别重要的一个元素：确定电压依赖的钙通道超家族中哪些成员负责进入神经末梢并引发化学递质的囊泡性释放。
Intracellular Ca2+initiates physiological events as diverse as gene transcription, muscle contraction, cell division and exocytosis. Predictably, the metabolic machinery that elicits and responds to changes in intracellular Ca2+is correspondingly heterogeneous. This review focuses on one element of this complex web that is of particular importance to neurobiologists: identifying which members of the voltage-dependent Ca2+-channel superfamily are responsible for the Ca2+that enters nerve terminals and elicits vesicular release of chemical transmitters.