[68Ga]PSMA-HBED uptake mimicking lymph node metastasis in coeliac ganglia: an important pitfall in clinical practice
[68Ga]PSMA-HBED uptake mimicking lymph node metastasis in coeliac ganglia: an important pitfall in clinical practice
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DOI：
10.1007/s00259-014-2915-3
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发表时间：
2015-02-01
影响因子：
9.1
通讯作者：
Behrendt, Florian F.
中科院分区：
文献类型：
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作者：
Krohn, Thomas;Verburg, Frederik A.;Behrendt, Florian F.
目的探讨[Ga-68]PSMA-HBED PET/CT患者腹腔神经节部位表面病理性腹膜后摄取的频率。方法本研究纳入85例前列腺癌患者进行[Ga-68]PSMA-HBED PET/CT检查。PET/CT扫描评估前列腺局部发现、淋巴结转移、远处转移和腹腔神经节的存在。确定相应的标准化摄取值（SUV）。计算神经节和淋巴结转移的SUVmax与背景摄取（臀肌SUVmean）之比。对神经节进行免疫组化。结果85例患者中76例（89.4%）至少有一个神经节出现示踪剂摄取。对于神经节，SUVmax和SUVmax与背景suv均值比值分别为2.97 +/- 0.88和7.98 +/- 2.84（范围为1.57 ~ 6.38和2.83 ~ 30.6），82.8%的神经节显示>5.0的摄取比。对于淋巴结转移，SUVmax和SUVmax与背景SUVmax的平均比值分别为8.5 +/- 7.0和23.31 +/- 22.23（范围2.06-35.9和5.25-115.8）。35例患者（41.2%）未发现淋巴结转移，但在神经节可见示踪剂摄取。免疫组化证实PSMA在神经节中表达强烈。结论大多数患者腹腔神经节显示相关的[Ga-68]PSMA-HBED摄取，并可能模拟淋巴结转移。
Purpose To determine the frequency of seemingly pathological retroperitoneal uptake in the location of the coeliac ganglia in patients undergoing [Ga-68]PSMA-HBED PET/CT.Methods The study included 85 men with prostate cancer referred for [Ga-68]PSMA-HBED PET/CT. The PET/CT scans were evaluated for the local finding in the prostate and the presence of lymph node metastases, distant metastases and coeliac ganglia. The corresponding standardized uptake values (SUV) were determined. SUVmax to background uptake (gluteal muscle SUVmean) ratios were calculated for the ganglia and lymph node metastases. Immunohistochemistry was performed on the ganglia.Results In 76 of the 85 patients (89.4 %) at least one ganglion with tracer uptake was found. For the ganglia, SUVmax and SUVmax to background SUVmean ratios were 2.97 +/- 0.88 and 7.98 +/- 2.84 (range 1.57-6.38 and 2.83-30.6), respectively, and 82.8% of all ganglia showed an uptake ratio of >5.0. For lymph node metastases, SUVmax and SUVmax to background SUVmean ratios were 8.5 +/- 7.0 and 23.31 +/- 22.23 (range 2.06-35.9 and 5.25-115.8), respectively. In 35 patients (41.2 %), no lymph node metastases were found but tracer uptake was seen in the ganglia. Immunohistochemistry confirmed strong PSMA expression in the ganglia.Conclusion Coeliac ganglia show a relevant [Ga-68]PSMA-HBED uptake in most patients and may mimic lymph node metastases.