Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 Predicts the Changes of Rheumatoid Factor Titers in Rheumatoid Arthritis.
Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 Predicts the Changes of Rheumatoid Factor Titers in Rheumatoid Arthritis.
复制标题
可溶性凝集素样氧化低密度脂蛋白受体 1 预测类风湿关节炎中类风湿因子滴度的变化。
DOI：
10.1097/rhu.0000000000001116
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Matsuda S.
中科院分区：
文献类型：
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作者：
Okahata A;Ito H;Furu M;Ishikawa M;Fujii T;Hashimoto M;Tanaka M;Morita Y;Azukizawa M;Tomizawa T;Doi K;Nishitani K;Murata K;Yoshitomi H;Mimori T;Matsuda S.
目的本纵向研究旨在探讨可溶性凝集素样氧化低密度脂蛋白受体1 （sLOX-1）在类风湿关节炎患者中的临床意义。方法：我们收集了一个大型类风湿关节炎队列在3个时间点的人口学和临床数据。在每个时间点采集血样；样本数量2012年为282例，2013年为431例，2014年为500例。采用酶联免疫吸附法测定血浆sLOX-1。分析sLOX-1与临床资料的相关性。通过多元线性回归分析与sLOX-1和类风湿因子（RF）变化相关的预测因素。结果
ObjectiveThe aim of this longitudinal study was to examine the clinical significance of soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) in patients with rheumatoid arthritis.MethodsWe gathered demographic and clinical data for a large rheumatoid arthritis cohort at 3 time points. Blood samples were collected at each time point; the number of samples was 282 cases in 2012, 431 cases in 2013, and 500 cases in 2014. Plasma sLOX-1 was measured by enzyme-linked immunosorbent assay. Correlations between sLOX-1 and clinical data were analyzed. Predictive factors associated with changes in sLOX-1 and rheumatoid factor (RF) were analyzed by multivariate linear regression.Results