IMPAIRED GLUCOSE-TOLERANCE AND ITS RELATIONSHIP TO ECG-INDICATED CORONARY HEART-DISEASE AND RISK-FACTORS AMONG CHINESE
IMPAIRED GLUCOSE-TOLERANCE AND ITS RELATIONSHIP TO ECG-INDICATED CORONARY HEART-DISEASE AND RISK-FACTORS AMONG CHINESE
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DOI：
10.2337/diacare.16.1.150
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发表时间：
1993-01-01
期刊：
影响因子：
16.2
通讯作者：
HOWARD, BV
中科院分区：
文献类型：
--
作者：
PAN, XR;HU, YH;HOWARD, BV
目的-确定糖耐量减低和糖尿病的患病率，并确定心血管疾病的发生及其危险因素。研究设计和方法-这项研究是一项基于人群的横断面研究，110，660名居民，25-74岁的大庆，黑龙江省，中国。IGT患者577例（5.5/1000），新诊断糖尿病患者630例（6.0/1000）。此外，还确定了190例（1.7/1000）既往已知患有糖尿病的患者。IGT患者中高血压、肥胖和白蛋白排泄异常的发生率是年龄和性别分布相似的279名男性和240名女性中OGTT正常者的两倍。IGT患者的血浆胆固醇和TG高于非糖尿病患者，HDL胆固醇低于非糖尿病患者。IGT患者的心电图CHD患病率是血糖正常者的9.5倍。IGT受试者血浆胰岛素浓度较高，但75 g葡萄糖负荷后1小时胰岛素-葡萄糖比率较低。在一个向前逐步多元Logistic回归分析，IGT本身仍然是一个独立的因素与CHD调整后的年龄，性别，吸烟，血浆胆固醇，血压，和obesity.CONCLUSIONS -因此，在中国，IGT可能会发生几乎一样高的频率糖尿病，并伴随着增加的频率CVD及其危险因素。这项研究的估计表明，在大庆地区人群中，所有ECG显示的CHD中有>12.0%发生在IGT和NIDDM患者中。在这项调查中确定的IGT受试者形成了长期随访和干预研究的队列。
OBJECTIVE - To determine the prevalence of IGT and diabetes and identify the occurrence of CVD and its risk factors.RESEARCH DESIGN AND METHODS - This study was a population-based, cross-sectional study of 110,660 residents, 25-74 yr of age of DaQing, Hei Long Jiang Province, China.RESULTS - Using 1985 WHO criteria, 577 (5.5/1000) subjects with IGT and 630 (6.0/1000) with newly diagnosed diabetes were identified. In addition, 190 (1.7/1000) with previously known diabetes were identified. Hypertension, obesity, and abnormal albumin excretion were twice as frequent in those with IGT as in 279 men and 240 women of similar age and sex distribution who had normal OGTTs. Plasma cholesterol and TGs were higher, and HDL cholesterol was lower in subjects with IGT than in nondiabetic subjects. Those with IGT had a prevalence of electrocardiographically recognized CHD 9.5-fold greater than the normoglycemic subjects. Subjects with IGT had higher plasma insulin concentrations, but the 1-h insulin-glucose ratio after the 75-g glucose load was lower. In a forward stepwise multiple logistic regression analysis, IGT itself remained an independent factor associated with CHD after adjustment for age, sex, cigarette smoking, plasma cholesterol, BP, and obesity.CONCLUSIONS - Therefore, in China, IGT may occur with almost as high a frequency as diabetes and is accompanied by an increased frequency of CVD and its risk factors. Estimates from this study indicate that >12.0% of all ECG-indicated CHD in the Da Qing population occurs in individuals with IGT and NIDDM. The IGT subjects identified in this survey form the cohort for a long-term follow-up and intervention study.