Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study
Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study
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DOI：
10.1136/jnnp.2003.029876
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发表时间：
2005-01-01
影响因子：
11
通讯作者：
Laakso, MP
中科院分区：
文献类型：
--
作者：
Frisoni, GB;Testa, C;Laakso, MP
目的：探讨阿尔茨海默病患者发病年龄与脑结构的相关性。方法：我们研究了9例早发(年龄小于或等于65岁)、9例晚发(年龄65岁)轻-中度阿尔茨海默病(Eoad和Load)的阿尔茨海默病患者，以及26名对照组，他们被分成年轻(YC，年龄小于或等于65岁，n=9)和老年(OC，年龄&>65，n=17)两组。两组患者的临床严重程度非常接近：3/2/3/1患者的临床痴呆评分分别为0.5/1/2/3。Eoad组和YC组以及Load组和OC组的高分辨率磁共振图像在逐个体素的基础上进行比较，以检测特定萎缩的区域。结果：Eoad组患者在颞顶交界处表现出更大的新皮质萎缩，而Load组患者表现为更大的海马区萎缩。结论：遗传因素在阿尔茨海默病的发病中起一定作用，环境因素在负荷中起重要作用，遗传因素和环境因素可能在阿尔茨海默病的发生发展中起不同的作用。
Objective: To examine the brain structural correlates of age at onset in patients with Alzheimer's disease.Methods: We studied nine patients with early onset ( age less than or equal to65 years), nine with late onset (age >65) Alzheimer's disease (EOAD and LOAD, respectively) of mild-moderate severity, and 26 controls who were stratified into younger (YC, age less than or equal to65, n = 9) and older (OC, age >65, n = 17) subjects. The patients were closely matched for clinical severity: 3/2/3/1 patients had clinical dementia rating of 0.5/1/2/3, respectively, in both the groups. High resolution magnetic resonance images of the brain of the EOAD and YC groups and the LOAD and OC groups were compared on a voxel by voxel basis with statistical parametric mapping to detect areas specifically atrophic.Results: The patients with EOAD showed greater neocortical atrophy at the temporoparietal junction while the patients with LOAD showed greater hippocampal atrophy. The results could not be accounted for by the apolipoprotein E genotype.Conclusions: Since genetic factors are believed to play a relevant pathogenetic role in EOAD and environmental factors in LOAD, genetic and environmental factors may differentially predispose the neocortical and limbic areas to the development of Alzheimer's neuropathology.