Suppression of aversive memories associates with changes in early and late stages of neurocognitive processing
Suppression of aversive memories associates with changes in early and late stages of neurocognitive processing
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厌恶记忆的抑制与神经认知处理早期和晚期的变化有关
DOI：
10.1016/j.neuropsychologia.2012.08.004
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发表时间：
2012-10-01
期刊：
影响因子：
2.6
通讯作者：
Luo, Yue-Jia
中科院分区：
文献类型：
--
作者：
Chen, Chunping;Liu, Chao;Luo, Yue-Jia
不想要的记忆，如情绪上的负面记忆，可以通过人类的自愿控制来有意抑制。记忆抑制被认为是由一系列神经认知过程的相互作用介导的。然而，缺乏支持这一概念的经验数据。我们使用高时间分辨率事件相关电位（ERP）技术，研究了年轻健康参与者在思考/不思考范式中与消极和中性记忆抑制相关的ERPs的时间过程。结果表明，与中性记忆相比，参与者在抑制情绪负面记忆方面有更大的困难。事件相关电位（ERPs）和源性分析表明，负性和中性记忆的抑制加工一般与70-260 ms时间窗内的早期成分P1和N2的变化有关，主要发生在右额下回和枕叶;厌恶性记忆的抑制与380和800 ms之间的两个主要晚期ERP成分有关，晚期负波（LN）显著较小，但晚期顶叶正波（LPP）较大，主要位于右侧额内侧回和额上级。这些结果表明，早期成分的差异可能反映了抑制加工的早期阶段，包括视觉意识，注意力重新分配和执行处理。厌恶性记忆和中性记忆抑制之间的晚期成分差异可能反映了前额叶和顶叶网络支持的有意识回忆的下调过程。较小的LN和较大的LPP可以证明，对这个过程的控制效果较差，这可能解释了情绪负面记忆更难被抑制的事实。总而言之，这些发现表明，抑制厌恶性记忆需要下调后期有意识的回忆，这可以从早期的视觉和注意力处理记忆抑制分离。(C)2012爱思唯尔有限公司版权所有。
Unwanted memories, such as emotionally negative, can be intentionally suppressed through voluntary control in humans. Memory suppression is thought to be mediated by the interplay of a chain of neurocognitive processes. However, empirical data in support of this notion is lacking. Using high-temporal resolution event-related potential (ERP) technique, we investigated the time course of ERPs associated with suppression of negative and neutral memories in a Think/No-Think paradigm in young, healthy participants. Results showed that participants had greater difficulty in suppressing emotionally negative memories than neutral ones. ERPs and source analyses demonstrated that memory suppression processing for negative and neutral memories were generally associated with changes during early components of a time window of 70-260 ms, such as P1 and N2, mainly at the right inferior frontal gyrus and occipital lobe; suppression of aversive memories was associated with two major late ERP components between 380 and 800 ms, with significantly smaller later negativity (LN) but larger late parietal positivity (LPP), primarily at the right medial and superior frontal gyri. These results suggest that differences in early components may reflect early stages of suppression processing including visual awareness, attention reallocation, and executive processing. Differences in late components between suppression of aversive and neutral memories may reflect a process of down-regulating conscious recollection of memory representations supported by prefrontal and parietal networks. A less effective control of this process, as evidenced by smaller LN and larger LPP, may explain the fact that emotionally negative memories were harder to be suppressed. Altogether, these findings suggest that suppression of aversive memories requires down-regulation of late conscious recollection, which can be dissociated from early visual and attention processing in memory suppression. (C) 2012 Elsevier Ltd. All rights reserved.